产品
编 号:F210970
分子式:C14H23ClN6O5
分子量:390.82
产品类型
结构图
CAS No: 175865-59-5
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产品详情
生物活性:
Valganciclovir hydrochloride is an orally active antiviral agent. Valganciclovir hydrochloride can inhibit the growth of adenoviruses and have a protective effect on immunosuppressed hamsters. Valganciclovir hydrochloride can be used for the research of Cytomegalovirus.
体内研究:
Valganciclovir (200 mg/kg,每日 2 次,灌胃,连续 16 天) 对静脉注射 5 型腺病毒攻击的免疫抑制仓鼠具有保护作用。Animal Model:Immunosuppressed hamsters
Dosage:200 mg/kg
Administration:Oral gavage (p.o.)
Result:Resulted in significantly smaller magnitude of weight loss for all groups.Reduced the liver pathology.
体外研究:
Valganciclovir (500 μM, 5-7 days) 抑制人腺病毒在 A549 细胞中的生长。Valganciclovir (0.003-10 mM, 10 min) 联合 ganciclovir (HY-13637) 抑制 Caco-2 细胞对甘氨酸肌氨酸的摄取。