产品
编 号：F209773
分子式：C19H18ClN3O4
分子量：387.82
分子式：C19H18ClN3O4
分子量：387.82
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
询价
询价
250mg
询价
询价
500mg
询价
询价
结构图
CAS No: 175013-18-0
产品详情
生物活性：
Pyraclostrobin is a highly effective and broad-spectrum strobilurin fungicide. Pyraclostrobin can induce oxidative DNA damage, mitochondrial dysfunction and autophagy through the activation of AMPK/mTOR signaling. Pyraclostrobin can be used to control crop diseases.
体内研究：
Pyraclostrobin (0.01-0.08 μmol/L，对斑马鱼幼鱼进行持续至受精后 72 小时的 Pyraclostrobin 暴露) 导致斑马鱼幼鱼肝肿大。Pyraclostrobin (0.001-0.02 mg/L，将鱼分配到含有 20 L 溶解 Pyraclostrobin 的容器中 7-28 天) 对斑马鱼肝脏中的 DNA 损伤和抗氧化酶活性有毒性作用。Pyraclostrobin (33-48 μg/L，受精后第 4 天的斑马鱼幼鱼被转移到 24 孔板中，并接受 Pyraclostrobin 直至受精后第 8 天) 对斑马鱼幼鱼有毒性作用。Animal Model:Zebrafish
Dosage:0.001 mg/L, 0.01 mg/L, 0.02 mg/L
Administration:Fish were assigned to a vessel containing 20 L of water dissolved Pyraclostrobin
Result:Showed higher ROS levels in zebrafish livers.Decreased SOD levels and increased MDA levels.Increased the olive tail moments as the dose increased on days 7, 14, 21, and 28.
Animal Model:Zebrafish larvae
Dosage:33 mg/L, 36 mg/L, 40 mg/L, 44 mg/L, 48 mg/L
Administration:Zebrafish larvae at 4 days post fertilization (dpf) were transferred into 24-well plates and subjected to pyraclostrobin until 8 dpf
Result:Damaged histological and subcellular structure of larval heart and brain.Changed the expression level of cardiac muscle contraction pathway- and neural-related genes and proteins.Impaired larval cardiac function and locomotor behavior.
体外研究：
Pyraclostrobin (10-80 μmol/L, 24 h) 在 HepG2 细胞中表现出毒性作用。Pyraclostrobin (10-80 μmol/L, 6 h) 诱导 HepG2 细胞 DNA 损伤和线粒体功能障碍。
Pyraclostrobin is a highly effective and broad-spectrum strobilurin fungicide. Pyraclostrobin can induce oxidative DNA damage, mitochondrial dysfunction and autophagy through the activation of AMPK/mTOR signaling. Pyraclostrobin can be used to control crop diseases.
体内研究：
Pyraclostrobin (0.01-0.08 μmol/L，对斑马鱼幼鱼进行持续至受精后 72 小时的 Pyraclostrobin 暴露) 导致斑马鱼幼鱼肝肿大。Pyraclostrobin (0.001-0.02 mg/L，将鱼分配到含有 20 L 溶解 Pyraclostrobin 的容器中 7-28 天) 对斑马鱼肝脏中的 DNA 损伤和抗氧化酶活性有毒性作用。Pyraclostrobin (33-48 μg/L，受精后第 4 天的斑马鱼幼鱼被转移到 24 孔板中，并接受 Pyraclostrobin 直至受精后第 8 天) 对斑马鱼幼鱼有毒性作用。Animal Model:Zebrafish
Dosage:0.001 mg/L, 0.01 mg/L, 0.02 mg/L
Administration:Fish were assigned to a vessel containing 20 L of water dissolved Pyraclostrobin
Result:Showed higher ROS levels in zebrafish livers.Decreased SOD levels and increased MDA levels.Increased the olive tail moments as the dose increased on days 7, 14, 21, and 28.
Animal Model:Zebrafish larvae
Dosage:33 mg/L, 36 mg/L, 40 mg/L, 44 mg/L, 48 mg/L
Administration:Zebrafish larvae at 4 days post fertilization (dpf) were transferred into 24-well plates and subjected to pyraclostrobin until 8 dpf
Result:Damaged histological and subcellular structure of larval heart and brain.Changed the expression level of cardiac muscle contraction pathway- and neural-related genes and proteins.Impaired larval cardiac function and locomotor behavior.
体外研究：
Pyraclostrobin (10-80 μmol/L, 24 h) 在 HepG2 细胞中表现出毒性作用。Pyraclostrobin (10-80 μmol/L, 6 h) 诱导 HepG2 细胞 DNA 损伤和线粒体功能障碍。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备