产品
编 号：F209497
分子式：C23H29NO6
分子量：415.48
分子式：C23H29NO6
分子量：415.48
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 174689-39-5
产品详情
生物活性：
SR59230A is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively.
体内研究：
MDMA (20 mg/kg) produces a slowly developing hyperthermia, reaching a maximum increase of 1.8°C at 130 min post injection. ?SR59230A (0.5 mg/kg) produces a small but significant attenuation of the slowly developing hyperthermia to MDMA. SR59230A (5 mg/kg) reveals a significant and marked early hypothermic reaction to MDMA.Animal Model:Male C-57BL6J wild-type mice (22-35 g)
Dosage:0.5 or 5 mg/kg
Administration:Injected s.c.; administered 30 min prior to the injection s.c. of MDMA (20 mg/kg).
Result:Modulated the actions of MDMA on temperature involve α1-adrenoceptor antagonism.
体外研究：
SR59230A (100 nM-50 μM; 24 hours) is able to reduce cell viability in a dose-dependent manner in Neuro-2A, BE(2)C and SK-N-BE(2) NB cell lines.
SR59230A is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively.
体内研究：
MDMA (20 mg/kg) produces a slowly developing hyperthermia, reaching a maximum increase of 1.8°C at 130 min post injection. ?SR59230A (0.5 mg/kg) produces a small but significant attenuation of the slowly developing hyperthermia to MDMA. SR59230A (5 mg/kg) reveals a significant and marked early hypothermic reaction to MDMA.Animal Model:Male C-57BL6J wild-type mice (22-35 g)
Dosage:0.5 or 5 mg/kg
Administration:Injected s.c.; administered 30 min prior to the injection s.c. of MDMA (20 mg/kg).
Result:Modulated the actions of MDMA on temperature involve α1-adrenoceptor antagonism.
体外研究：
SR59230A (100 nM-50 μM; 24 hours) is able to reduce cell viability in a dose-dependent manner in Neuro-2A, BE(2)C and SK-N-BE(2) NB cell lines.
产品资料
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