产品
编 号：F209425
分子式：C25H20N2O3
分子量：396.44
分子式：C25H20N2O3
分子量：396.44
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 174635-53-1
产品详情
生物活性：
SB 218795 is a potent and selective non-peptide NK3 receptor antagonist, with a Ki 13 nM for hNK3. SB 218795 shows about 90-fold and 7000-fold selectivity for hNK3 over hNK2 and hNK1, respectively. SB 218795 can inhibit NK3 receptor-mediated pupillary constriction of the rabbit.
体内研究：
SB?218795 (0.25-1?mg/kg; i.v.) inhibits Senktide-induced miosis in rabbits by the maximum inhibition of 78%.
体外研究：
SB 218795 (3-30 nM) antagonizes the contractile responses induced by the NK3 receptor agonist senktide in a surmountable and concentration-dependent manner.SB 218795 (0.3-3?μM) does not affect the contractile responses of the NK3 receptor agonist [MePhe7]-NKB in the rabbit iris sphincter muscle.
SB 218795 is a potent and selective non-peptide NK3 receptor antagonist, with a Ki 13 nM for hNK3. SB 218795 shows about 90-fold and 7000-fold selectivity for hNK3 over hNK2 and hNK1, respectively. SB 218795 can inhibit NK3 receptor-mediated pupillary constriction of the rabbit.
体内研究：
SB?218795 (0.25-1?mg/kg; i.v.) inhibits Senktide-induced miosis in rabbits by the maximum inhibition of 78%.
体外研究：
SB 218795 (3-30 nM) antagonizes the contractile responses induced by the NK3 receptor agonist senktide in a surmountable and concentration-dependent manner.SB 218795 (0.3-3?μM) does not affect the contractile responses of the NK3 receptor agonist [MePhe7]-NKB in the rabbit iris sphincter muscle.
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