产品
编 号：F024475
分子式：C9H9N3O2
分子量：191.19
分子式：C9H9N3O2
分子量：191.19
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
400
In-stock
500mg
560
In-stock
1g
720
In-stock
5g
2160
In-stock
结构图
CAS No: 10605-21-7
产品详情
生物活性：
Carbendazim is a potent and orally active broad-spectrum?benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as Seproria,?Fusarium?and?Sclerotina. Carbendazim is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma.
体内研究：
Carbendazim (口服灌胃；100, 500 mg/kg；饮食中每天一次；28 天) 诱导肝脏脂质代谢紊乱，导致小鼠肝脏脂质积累和甘油三酯 (TG) 水平显著增加。Animal Model:6-week-old male ICR mice
Dosage:100 and 500 mg/kg
Administration:Oral gavage; 100 and 500 mg/kg; once daily in diet; 28 days
Result:Increased the relative mRNA levels of some key genes related to lipogenesis and TG synthesis.Up-regulated mRNA levels of IL-1b and IL-6 in the liver in mice.Increased the serum concentrations of 2 proinflammatory cytokines IL-1b and IL-6 at 500 mg/kg. However, in the fat tissues, onlyIL-1b in the CBZ-500-treated group increased significantly as compared with the control group.
体外研究：
在 CCK-8 检测中，Carbendazim (4-60 μM；24 h) 对 HeLa 细胞的活力没有影响。
Carbendazim is a potent and orally active broad-spectrum?benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as Seproria,?Fusarium?and?Sclerotina. Carbendazim is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma.
体内研究：
Carbendazim (口服灌胃；100, 500 mg/kg；饮食中每天一次；28 天) 诱导肝脏脂质代谢紊乱，导致小鼠肝脏脂质积累和甘油三酯 (TG) 水平显著增加。Animal Model:6-week-old male ICR mice
Dosage:100 and 500 mg/kg
Administration:Oral gavage; 100 and 500 mg/kg; once daily in diet; 28 days
Result:Increased the relative mRNA levels of some key genes related to lipogenesis and TG synthesis.Up-regulated mRNA levels of IL-1b and IL-6 in the liver in mice.Increased the serum concentrations of 2 proinflammatory cytokines IL-1b and IL-6 at 500 mg/kg. However, in the fat tissues, onlyIL-1b in the CBZ-500-treated group increased significantly as compared with the control group.
体外研究：
在 CCK-8 检测中，Carbendazim (4-60 μM；24 h) 对 HeLa 细胞的活力没有影响。
产品资料
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