产品
编 号：F208813
分子式：C20H28O2
分子量：300.44
分子式：C20H28O2
分子量：300.44
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
560
In-stock
10mg
960
In-stock
20mg
1600
In-stock
结构图
CAS No: 1740-19-8
产品详情
生物活性：
Dehydroabietic acid is a diterpene resin acid that can be isolated from Pinus and Picea. Dehydroabietic acid has anti-bacterial, anti-fungal, anti-inflammatory, and anticancer activities. Dehydroabietic acid is a dual PPAR-α/γ agonist and PPAR-γ partial agonist, which can attenuate insulin resistance (IR) and hepatic steatosis induced by HFD-consumption in mice.
体内研究：
Dehydroabietic acid (10-20 mg/kg, 灌胃, 每日一次, 9 周) 在 HFD 小鼠中可减轻 HFD 诱导的肝脏脂肪变性和炎症。Animal Model:HFD mice
Dosage:10-20 mg/kg
Administration:i.g., daily, 9 weeks
Result:Decreased the levels of liver injury markers, ALT and AST.Decreased blood TG, TC and LDL-c levels and increased the HDL-c levels.Activated PPAR-α and its target gene which were reduced by HFD, including acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain and CPT1α.Decreased mRNA expression of inflammatory factors commonly involved in liver diseases and injury (IL-1β, IL-6, TNF-α, COX-1 and COX-2).Upregulated mRNA expression of PPAR-γ, Glut-4, Adipor, FSP27, ACOX-1, FABP4, Adiponectin.
体外研究：
Dehydroabietic acid (0-100 μM, 30 min) 可减少 RAW264.7 细胞中 NO 的产生。Dehydroabietic acid (0-100 μM, 6 h) 可降低 RAW264.7 细胞中炎症介质的 mRNA 表达水平，包括诱导型一氧化氮 (iNOS) 和 TNF-α。Dehydroabietic acid (0-100 μM, 24 h) 可降低 HEK293T 细胞中 MyD88 诱导的 NF-κB 和 AP-1 转录活性。Dehydroabietic acid (100 μM, 24 h) 可使 Src 或 Syk 过表达 HEK293T 细胞中的 Src 和 Syk 激酶失活。Dehydroabietic acid (2.5-15 μM, 4 days) 以剂量依赖性方式促进 3T3-L1 脂肪细胞分化。Dehydroabietic acid (10 μM, 0-6 days) 可增加 3T3-L1 细胞中 PPAR-γ 靶基因 (Glut-4 和 Cyp4a10) 的 mRNA 表达。
Dehydroabietic acid is a diterpene resin acid that can be isolated from Pinus and Picea. Dehydroabietic acid has anti-bacterial, anti-fungal, anti-inflammatory, and anticancer activities. Dehydroabietic acid is a dual PPAR-α/γ agonist and PPAR-γ partial agonist, which can attenuate insulin resistance (IR) and hepatic steatosis induced by HFD-consumption in mice.
体内研究：
Dehydroabietic acid (10-20 mg/kg, 灌胃, 每日一次, 9 周) 在 HFD 小鼠中可减轻 HFD 诱导的肝脏脂肪变性和炎症。Animal Model:HFD mice
Dosage:10-20 mg/kg
Administration:i.g., daily, 9 weeks
Result:Decreased the levels of liver injury markers, ALT and AST.Decreased blood TG, TC and LDL-c levels and increased the HDL-c levels.Activated PPAR-α and its target gene which were reduced by HFD, including acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain and CPT1α.Decreased mRNA expression of inflammatory factors commonly involved in liver diseases and injury (IL-1β, IL-6, TNF-α, COX-1 and COX-2).Upregulated mRNA expression of PPAR-γ, Glut-4, Adipor, FSP27, ACOX-1, FABP4, Adiponectin.
体外研究：
Dehydroabietic acid (0-100 μM, 30 min) 可减少 RAW264.7 细胞中 NO 的产生。Dehydroabietic acid (0-100 μM, 6 h) 可降低 RAW264.7 细胞中炎症介质的 mRNA 表达水平，包括诱导型一氧化氮 (iNOS) 和 TNF-α。Dehydroabietic acid (0-100 μM, 24 h) 可降低 HEK293T 细胞中 MyD88 诱导的 NF-κB 和 AP-1 转录活性。Dehydroabietic acid (100 μM, 24 h) 可使 Src 或 Syk 过表达 HEK293T 细胞中的 Src 和 Syk 激酶失活。Dehydroabietic acid (2.5-15 μM, 4 days) 以剂量依赖性方式促进 3T3-L1 脂肪细胞分化。Dehydroabietic acid (10 μM, 0-6 days) 可增加 3T3-L1 细胞中 PPAR-γ 靶基因 (Glut-4 和 Cyp4a10) 的 mRNA 表达。
产品资料
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