产品
编 号：F208788
分子式：C14H15F2N3S
分子量：295.35
分子式：C14H15F2N3S
分子量：295.35
产品类型
规格
价格
是否有货
结构图
CAS No: 173997-05-2
产品详情
生物活性：
Nepicastat (SYN117) is a selective, potent, and orally active inhibitor of dopamine-beta-hydroxylase. Nepicastat (SYN117) produces concentration-dependent inhibition of bovine (IC50=8.5 nM) and human (IC50=9 nM) dopamine-beta-hydroxylase. Nepicastat (SYN117) can cross the blood-brain barrier (BBB).
体内研究：
Nepicastat (3-100 mg/kg; p.o.; three consecutive times, 12 hours apart times) produces dose-dependent decreases in noradrenaline content, increases in dopamine content and increases in dopamine/noradrenaline ratio in the artery (mesenteric or renal), left ventricle.Animal Model:15-16 weeks male spontaneously hypertensive rats (SHRs)
Dosage:Oral administration; three consecutive times, 12 hours apart
Administration:3, 10, 30, 100 mg/kg
Result:Produced dose-dependent decreases in noradrenaline content, increases in dopamine content and increases in dopamine/noradrenaline ratio in the artery (mesenteric or renal), left ventricle and cerebral cortex.
Nepicastat (SYN117) is a selective, potent, and orally active inhibitor of dopamine-beta-hydroxylase. Nepicastat (SYN117) produces concentration-dependent inhibition of bovine (IC50=8.5 nM) and human (IC50=9 nM) dopamine-beta-hydroxylase. Nepicastat (SYN117) can cross the blood-brain barrier (BBB).
体内研究：
Nepicastat (3-100 mg/kg; p.o.; three consecutive times, 12 hours apart times) produces dose-dependent decreases in noradrenaline content, increases in dopamine content and increases in dopamine/noradrenaline ratio in the artery (mesenteric or renal), left ventricle.Animal Model:15-16 weeks male spontaneously hypertensive rats (SHRs)
Dosage:Oral administration; three consecutive times, 12 hours apart
Administration:3, 10, 30, 100 mg/kg
Result:Produced dose-dependent decreases in noradrenaline content, increases in dopamine content and increases in dopamine/noradrenaline ratio in the artery (mesenteric or renal), left ventricle and cerebral cortex.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备