产品
编 号：F208719
分子式：C12H12O4
分子量：220.22
分子式：C12H12O4
分子量：220.22
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
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询价
结构图
CAS No: 173933-40-9
产品详情
生物活性：
Hispolon, a polyphenol, can be isolated from Phellinus linteus. Hispolon possesses anticancer, antidiabetic, antioxidant, antiviral, hepatoprotective, anti-diabetic, and anti-inflammatory activities.
体内研究：
Hispolon (2.5-10 mg/kg, i.p.) attenuates LPS-induced acute lung injury in mice.Hispolon (5 and 10 mg/kg, s.c.) reduces tumor growth in DBTRG xenograft mice.Animal Model:LPS-induced acute lung injury mice
Dosage:2.5, 5 and 10 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Alleviated the pathological effects in the LPS-challenged mouse.Reduced the W/D ratio in the lung and MPO activity.Decreased pro-Inflammatory cytokine production.
Animal Model:DBTRG xenograft mice
Dosage:5 and 10 mg/kg
Administration:Subcutaneous injection (s.c.)
Result:Reduced tumor volume (RTV).Inhibited GBM cell proliferation in vivo upon HE and ki-67 staining.
体外研究：
Hispolon (25 and 50 μM, 24-72 h) inhibits cell viability of U87MG cells.Hispolon (25 and 50 μM, 24, 48 h) induces G2/M cell cycle arrest and apoptosis in U87MG cells.Hispolon (25 and 50 μM, 2-8 h) decreases the expression of G1–S transition-related protein cyclin D4 but increases the expression of CDK inhibitor p21.Hispolon (25 and 50 μM, 24 h) inhibits the migration of U87MG cells.
Hispolon, a polyphenol, can be isolated from Phellinus linteus. Hispolon possesses anticancer, antidiabetic, antioxidant, antiviral, hepatoprotective, anti-diabetic, and anti-inflammatory activities.
体内研究：
Hispolon (2.5-10 mg/kg, i.p.) attenuates LPS-induced acute lung injury in mice.Hispolon (5 and 10 mg/kg, s.c.) reduces tumor growth in DBTRG xenograft mice.Animal Model:LPS-induced acute lung injury mice
Dosage:2.5, 5 and 10 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Alleviated the pathological effects in the LPS-challenged mouse.Reduced the W/D ratio in the lung and MPO activity.Decreased pro-Inflammatory cytokine production.
Animal Model:DBTRG xenograft mice
Dosage:5 and 10 mg/kg
Administration:Subcutaneous injection (s.c.)
Result:Reduced tumor volume (RTV).Inhibited GBM cell proliferation in vivo upon HE and ki-67 staining.
体外研究：
Hispolon (25 and 50 μM, 24-72 h) inhibits cell viability of U87MG cells.Hispolon (25 and 50 μM, 24, 48 h) induces G2/M cell cycle arrest and apoptosis in U87MG cells.Hispolon (25 and 50 μM, 2-8 h) decreases the expression of G1–S transition-related protein cyclin D4 but increases the expression of CDK inhibitor p21.Hispolon (25 and 50 μM, 24 h) inhibits the migration of U87MG cells.
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