产品
编 号：F208717
分子式：C38H46O8
分子量：630.77
分子式：C38H46O8
分子量：630.77
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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结构图
CAS No: 173932-75-7
产品详情
生物活性：
Gambogenic acid is an active ingredient that can be isolated from gamboge. Gambogenic acid acts as an effective inhibitor of EZH2, specifically and covalently binds to Cys668 within the EZH2-SET domain, and induces EZH2 ubiquitination. Gambogenic acid can be used for the research of cancer.
体内研究：
Gambogenic Acid (4-12 mg/kg，静脉注射，每 2 天一次，14 天) 可抑制 SCLC 小鼠异种移植模型中的肿瘤生长。Animal Model:SCLC mouse xenograft model
Dosage:4-12 mg/kg
Administration:i.v., every 2 days, 14 days
Result:Increased the expression of pro-apoptotic proteins (cleaved caspase-3, -8 and -9, Bax, cleaved PARP and p53 proteins).Decreased the anti-apoptotic proteins (Bcl-2).
体外研究：
Gambogenic Acid (0.6-2.4 μM, 1.2-3.2 μM; 24-72 h) 抑制 SCLC 细胞系 (NCI-H446/NCI-H1688) 的增殖。Gambogenic acid (0.6-1.2 μM, 1.5-2.2 μM; 24 h) 将 SCLC 细胞系 (NCI-H446/NCI-H1688) 的细胞周期进程阻滞在不同阶段。Gambogenic acid (1.4-2 μM, 2.4-3 μM; 24 h) 以剂量依赖性方式增加 SCLC 细胞系 (NCI-H446/NCI-H1688) 的细胞凋亡率.
Gambogenic acid is an active ingredient that can be isolated from gamboge. Gambogenic acid acts as an effective inhibitor of EZH2, specifically and covalently binds to Cys668 within the EZH2-SET domain, and induces EZH2 ubiquitination. Gambogenic acid can be used for the research of cancer.
体内研究：
Gambogenic Acid (4-12 mg/kg，静脉注射，每 2 天一次，14 天) 可抑制 SCLC 小鼠异种移植模型中的肿瘤生长。Animal Model:SCLC mouse xenograft model
Dosage:4-12 mg/kg
Administration:i.v., every 2 days, 14 days
Result:Increased the expression of pro-apoptotic proteins (cleaved caspase-3, -8 and -9, Bax, cleaved PARP and p53 proteins).Decreased the anti-apoptotic proteins (Bcl-2).
体外研究：
Gambogenic Acid (0.6-2.4 μM, 1.2-3.2 μM; 24-72 h) 抑制 SCLC 细胞系 (NCI-H446/NCI-H1688) 的增殖。Gambogenic acid (0.6-1.2 μM, 1.5-2.2 μM; 24 h) 将 SCLC 细胞系 (NCI-H446/NCI-H1688) 的细胞周期进程阻滞在不同阶段。Gambogenic acid (1.4-2 μM, 2.4-3 μM; 24 h) 以剂量依赖性方式增加 SCLC 细胞系 (NCI-H446/NCI-H1688) 的细胞凋亡率.
产品资料
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