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编 号:F208708
分子式:C22H28N2O4
分子量:384.47
产品类型
结构图
CAS No: 17391-18-3
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Corynoxine B is an oxindole alkaloid isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese); a Beclin-1-dependent autophagy inducer. IC50 value:Target: Autophagy inducerin vitro: Corynoxine B, a natural autophagy inducer, restores the deficient cytosolic translocation of HMGB1 and autophagy in cells overexpressing SNCA, which may be attributed to its ability to block SNCA-HMGB1 interaction .in vivo: Corynoxine B exhibited prolongation of the thiopental-induced hypnosis on oral administration in mice .