产品
编 号：F208692
分子式：C10H7N3O4S
分子量：265.25
分子式：C10H7N3O4S
分子量：265.25
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
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10mg
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50mg
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100mg
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结构图
CAS No: 173903-47-4
产品详情
生物活性：
Tizoxanide (TIZ) is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide (TIZ) has anti-HIV-1 activities and potent inhibition of both HBV and HCV replication with values EC50 of 0.46μM and 0.15 μM, respectively. Tizoxanide also exerts anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines and suppressing of the activation of the NF-κB and the MAPK signaling pathways in LPS-treated macrophage cells.
体内研究：
Tizoxanide (TIZ)(10 mg/kg; i.v.) can pass the BBB and distribute to the brain tissue. Tizoxanide retains in brain is obviously longer than that in plasma.Animal Model:Sprague Dawley rats
Dosage:10 mg/kg
Administration:Tizoxanide (10 mg/kg; i.v.)
Result:Could pass the BBB and distribute to the brain tissue.
体外研究：
Tizoxanide (TIZ)induces mild mitochondrial uncoupling and activate AMPK in hepatocytes.Tizoxanide (TIZ)inhibits hepatitis C virus (HCV) replication in HCV replicon systems.
Tizoxanide (TIZ) is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide (TIZ) has anti-HIV-1 activities and potent inhibition of both HBV and HCV replication with values EC50 of 0.46μM and 0.15 μM, respectively. Tizoxanide also exerts anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines and suppressing of the activation of the NF-κB and the MAPK signaling pathways in LPS-treated macrophage cells.
体内研究：
Tizoxanide (TIZ)(10 mg/kg; i.v.) can pass the BBB and distribute to the brain tissue. Tizoxanide retains in brain is obviously longer than that in plasma.Animal Model:Sprague Dawley rats
Dosage:10 mg/kg
Administration:Tizoxanide (10 mg/kg; i.v.)
Result:Could pass the BBB and distribute to the brain tissue.
体外研究：
Tizoxanide (TIZ)induces mild mitochondrial uncoupling and activate AMPK in hepatocytes.Tizoxanide (TIZ)inhibits hepatitis C virus (HCV) replication in HCV replicon systems.
产品资料
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