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编 号:F208182
分子式:C15H22ClN3O2S
分子量:343.87
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10mM*1mL in DMSO
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2mg
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5mg
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10mg
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生物活性:
Fabomotizole hydrochloride (CM346 hydrochloride) is an anxiolytic agent. Fabomotizole hydrochloride produces anxiolytic and neuroprotective effects without any muscle relaxant actions.

体外研究:
Afobazole's mechanism of action remains poorly defined however, with GABAergic, NGF and BDNF release promoting, MT1 receptor antagonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Afobazole was shown to inhibit MAO-A reversibly and there might be also some involvement with serotonin receptors. Afobazole has found little clinical use outside of Russia and has not been evaluated by the FDA.
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