产品
编 号：F207731
分子式：C21H24Cl2N2O2
分子量：407.33
分子式：C21H24Cl2N2O2
分子量：407.33
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 172895-39-5
产品详情
生物活性：
LY266097 hydrochloride is a selective 5-HT2B receptor antagonist with pKis of 7.7, 9.8, and 7.6 for 5-HT2A, 5-HT2B, 5-HT2C, respectively. 5-HT2B receptor blockade contributes to the research in depression.
体内研究：
LY266097 (0.6?mg/kg for 2-day administration) rescues Escitalopram-induced decrease in dopamine (DA) .The administration of LY266097 alone or its addition on the last 3 days of a 14-day Escitalopram regimen increases pyramidal neuron firing and burst activity.Animal Model:Male Sprague-Dawley rats weighing 250-350?g
Dosage:0.6?mg/kg
Administration:Administered i.p. alone or concomitantly with Escitalopram (2?mg/kg) for 2 days
Result:Short-term administration (0.6?mg/kg/day for 2 days; i.p.) alone had no effect on these parameters, its co-administration counteracted the inhibitory effect of escitalopram on the firing activity of DA neurons, resulting in a recovery to control level.
体外研究：
LY266097 is a highly selective 5-HT2B receptor antagonist with a pKi of 9.7 for the human cloned 5-HT2B receptor and a 100-fold greater selectivity over human 5-HT2C and 5-HT2A sites.
LY266097 hydrochloride is a selective 5-HT2B receptor antagonist with pKis of 7.7, 9.8, and 7.6 for 5-HT2A, 5-HT2B, 5-HT2C, respectively. 5-HT2B receptor blockade contributes to the research in depression.
体内研究：
LY266097 (0.6?mg/kg for 2-day administration) rescues Escitalopram-induced decrease in dopamine (DA) .The administration of LY266097 alone or its addition on the last 3 days of a 14-day Escitalopram regimen increases pyramidal neuron firing and burst activity.Animal Model:Male Sprague-Dawley rats weighing 250-350?g
Dosage:0.6?mg/kg
Administration:Administered i.p. alone or concomitantly with Escitalopram (2?mg/kg) for 2 days
Result:Short-term administration (0.6?mg/kg/day for 2 days; i.p.) alone had no effect on these parameters, its co-administration counteracted the inhibitory effect of escitalopram on the firing activity of DA neurons, resulting in a recovery to control level.
体外研究：
LY266097 is a highly selective 5-HT2B receptor antagonist with a pKi of 9.7 for the human cloned 5-HT2B receptor and a 100-fold greater selectivity over human 5-HT2C and 5-HT2A sites.
产品资料
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