产品
编 号：F206434
分子式：C22H22F3N3O3S2
分子量：497.55
分子式：C22H22F3N3O3S2
分子量：497.55
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 1714146-59-4
产品详情
生物活性：
I-BRD9 is a selective cellular chemical probe of bromodomain-containing protein 9 (BRD9) with pIC50 value of 7.3 μM. I-BRD9 has high selectivity for bromodomain and extra terminal domain (BET) family and highly homologous bromodomain-containing protein 7 (BRD7). I-BRD9 can be used to identify genes regulated by BRD9 in Kasumi-1 cells involved in oncology and immune response pathways.
体外研究：
I-BRD9 (10 μM, 6 h) has a regulation role in cancer and immunology pathways.I-BRD9 (10 μM) has high BRD9 affinity and excellent broader bromodomain selectivity.I-BRD9 (10 μM) has affinity for BRD9 (TR-FRET), BRD4 BD1 (TR-FRET) and BRD9 NanoBRET with pIC50 values of 7.3 μM, 5.3 μM and 6.8 μM.I-BRD9 (10 μM) has high aqueous solubility (CLND) with 359 μM.I-BRD9 (10 μM) displays >625 fold selectivity in binding with endogenous BRD9 against BET family member BRD3 in HUT-78 cell lysate.
I-BRD9 is a selective cellular chemical probe of bromodomain-containing protein 9 (BRD9) with pIC50 value of 7.3 μM. I-BRD9 has high selectivity for bromodomain and extra terminal domain (BET) family and highly homologous bromodomain-containing protein 7 (BRD7). I-BRD9 can be used to identify genes regulated by BRD9 in Kasumi-1 cells involved in oncology and immune response pathways.
体外研究：
I-BRD9 (10 μM, 6 h) has a regulation role in cancer and immunology pathways.I-BRD9 (10 μM) has high BRD9 affinity and excellent broader bromodomain selectivity.I-BRD9 (10 μM) has affinity for BRD9 (TR-FRET), BRD4 BD1 (TR-FRET) and BRD9 NanoBRET with pIC50 values of 7.3 μM, 5.3 μM and 6.8 μM.I-BRD9 (10 μM) has high aqueous solubility (CLND) with 359 μM.I-BRD9 (10 μM) displays >625 fold selectivity in binding with endogenous BRD9 against BET family member BRD3 in HUT-78 cell lysate.
产品资料
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