产品
编 号：F206123
分子式：C12H14KN2O8V
分子量：404.29
分子式：C12H14KN2O8V
分子量：404.29
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 171202-16-7
产品详情
生物活性：
bpV(phen) trihydrate, a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC50s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and PTP-1B, respectively. bpV(phen) trihydrate inhibits proliferation of the protozoan parasite Leishmania in vitro. bpV(phen) trihydrate strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFNγ). bpV(phen) trihydrate can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity.
体内研究：
bpV (phen) (5 mg/kg；腹膜内注射；每天；持续 38 天；雄性 BALB/c 裸 (nu/nu) 无胸腺小鼠) 处理导致平均肿瘤体积显著减小。Animal Model:Male BALB/c nude (nu/nu) athymic mice (6-7 weeks old) injected with PC-3 cells
Dosage:5 mg/kg
Administration:Intraperitoneal injection; daily; for 38 days
Result:Caused a significant reduction in average tumor volume.
体外研究：
bpV (phen) (5 μM；24.5 小时；H9c2 细胞) 处理导致 H/R 损伤的 H9c2 细胞的细胞活力进一步降低。 bpV (phen) (5 μM；24.5 小时；H9c2 细胞) 处理增加 H/R 损伤的 H9c2 细胞的凋亡。 bpV (phen) (5 μM；24.5 小时；H9c2 细胞) 处理显著促进 H/R 损伤的 H9c2 细胞中细胞质细胞色素 C 的积累。用 bpV (phen) 刺激后，PTEN 诱导的推定激酶蛋白 1 (PINK1)/Parkin 介导的线粒体自噬受到抑制。bpV (phen) 是胰岛素受体酪氨酸激酶过度磷酸化和激活后的胰岛素模拟剂。
bpV(phen) trihydrate, a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC50s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and PTP-1B, respectively. bpV(phen) trihydrate inhibits proliferation of the protozoan parasite Leishmania in vitro. bpV(phen) trihydrate strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFNγ). bpV(phen) trihydrate can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity.
体内研究：
bpV (phen) (5 mg/kg；腹膜内注射；每天；持续 38 天；雄性 BALB/c 裸 (nu/nu) 无胸腺小鼠) 处理导致平均肿瘤体积显著减小。Animal Model:Male BALB/c nude (nu/nu) athymic mice (6-7 weeks old) injected with PC-3 cells
Dosage:5 mg/kg
Administration:Intraperitoneal injection; daily; for 38 days
Result:Caused a significant reduction in average tumor volume.
体外研究：
bpV (phen) (5 μM；24.5 小时；H9c2 细胞) 处理导致 H/R 损伤的 H9c2 细胞的细胞活力进一步降低。 bpV (phen) (5 μM；24.5 小时；H9c2 细胞) 处理增加 H/R 损伤的 H9c2 细胞的凋亡。 bpV (phen) (5 μM；24.5 小时；H9c2 细胞) 处理显著促进 H/R 损伤的 H9c2 细胞中细胞质细胞色素 C 的积累。用 bpV (phen) 刺激后，PTEN 诱导的推定激酶蛋白 1 (PINK1)/Parkin 介导的线粒体自噬受到抑制。bpV (phen) 是胰岛素受体酪氨酸激酶过度磷酸化和激活后的胰岛素模拟剂。
产品资料
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