产品
编 号：F205806
分子式：C9H11N5O3
分子量：237.22
分子式：C9H11N5O3
分子量：237.22
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CAS No: 17094-01-8
产品详情
生物活性：
L-Sepiapterin (Sepiapterin) is a precursor of the endothelial nitric oxide synthase (eNOS) cofactor tetrahydrobiopterin (BH4). L-Sepiapterin improves endothelial dysfunction in small mesenteric arteries from db/db mice, and induces angiogenesis. L-Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70S6K-dependent VEGFR-2 expression.
体内研究：
Sepiapterin (10 mg/kg; p.o. (powder chow); daily for or 8 weeks) significantly improves the relaxation to Ach in small mesenteric arteries (SMA) from db/db mice.Animal Model:Male C57BL/KsJ diabetic mice (db/db)
Dosage:10 mg/kg
Administration:P.o. (powder chow); daily for or 8 weeks
Result:Significantly improved the relaxation to Ach in SMA from db/db mice.
体外研究：
L-Sepiapterin (Sepiapterin) (0.1-10 μM; 24 hpurs) Iinduces cell proliferation in a dose-dependent manner.L-Sepiapterin (1-50 μM; 20 minutes) significantly inhibits the phosphorylation of VEGF-A-induced (50 ng/ml) p70S6K.L-Sepiapterin inhibits VEGF-A-induced cell proliferation and migration through NO-independent mechanism.
L-Sepiapterin (Sepiapterin) is a precursor of the endothelial nitric oxide synthase (eNOS) cofactor tetrahydrobiopterin (BH4). L-Sepiapterin improves endothelial dysfunction in small mesenteric arteries from db/db mice, and induces angiogenesis. L-Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70S6K-dependent VEGFR-2 expression.
体内研究：
Sepiapterin (10 mg/kg; p.o. (powder chow); daily for or 8 weeks) significantly improves the relaxation to Ach in small mesenteric arteries (SMA) from db/db mice.Animal Model:Male C57BL/KsJ diabetic mice (db/db)
Dosage:10 mg/kg
Administration:P.o. (powder chow); daily for or 8 weeks
Result:Significantly improved the relaxation to Ach in SMA from db/db mice.
体外研究：
L-Sepiapterin (Sepiapterin) (0.1-10 μM; 24 hpurs) Iinduces cell proliferation in a dose-dependent manner.L-Sepiapterin (1-50 μM; 20 minutes) significantly inhibits the phosphorylation of VEGF-A-induced (50 ng/ml) p70S6K.L-Sepiapterin inhibits VEGF-A-induced cell proliferation and migration through NO-independent mechanism.
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