产品
编 号：F205653
分子式：C11H13NO4
分子量：223.23
分子式：C11H13NO4
分子量：223.23
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规格
价格
是否有货
5mg
询价
询价
10mg
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询价
25mg
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50mg
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100mg
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结构图
CAS No: 170846-89-6
产品详情
生物活性：
E4CPG ((RS)-ECPG) is a Group I/Group II metabotropic glutamate receptor (mGluR) antagonist. E4CPG can inhibit the paired-pulse ratio of monosynaptic inhibitory postsynaptic currents (IPSC) potentiation.
体内研究：
E4CPG (3-30 nmol/site (i.t.), 1-10 μmol/paw(i.pl.), and 1-10 nmol/site (i.c.v.)) significantly inhibits the nociception induced by the Glutamate-injection (i.pl.; 30 μmol/paw), and the maximal inhibition valuesfor the antinociceptive action of E4CPG in Glutamate-induced nociception are 48% (i.pl.),49% (i.t.) and 40% (i.c.v.) . E4CPG (35 nM/3.5 μL, i.c.v.) completely blocks long-term depression (LTD) induced by the group I mGluR agonist Dihydroxyphenylglycine (DHPG, 100 nM/5 μL, i.c.v.) in male Sprague-Dawley rats.Animal Model:Male Swiss mice (25-35 g)
Dosage:3-30 nmol/site (i.t.), 1-10 μmol/paw(i.pl.) and 1-10 nmol/ site (i.c.v.)
Administration:Single injection
Result:The maximal inhibition values for the antinociceptive action of E4CPG in glutamate-induced nociception were 48% (i.pl.), 49% (i.t.) and 40% (i.c.v.).
Animal Model:Male Sprague-Dawley rats
Dosage:35 nM/3.5 μL
Administration:Single injection, i.c.v.
Result:Completely blocked LTD induced by the group I mGluR agonist dihydroxyphenylglycine (DHPG).
体外研究：
E4CPG acts at rat cortical mGluR with the KB value of 0.367 mM.
E4CPG ((RS)-ECPG) is a Group I/Group II metabotropic glutamate receptor (mGluR) antagonist. E4CPG can inhibit the paired-pulse ratio of monosynaptic inhibitory postsynaptic currents (IPSC) potentiation.
体内研究：
E4CPG (3-30 nmol/site (i.t.), 1-10 μmol/paw(i.pl.), and 1-10 nmol/site (i.c.v.)) significantly inhibits the nociception induced by the Glutamate-injection (i.pl.; 30 μmol/paw), and the maximal inhibition valuesfor the antinociceptive action of E4CPG in Glutamate-induced nociception are 48% (i.pl.),49% (i.t.) and 40% (i.c.v.) . E4CPG (35 nM/3.5 μL, i.c.v.) completely blocks long-term depression (LTD) induced by the group I mGluR agonist Dihydroxyphenylglycine (DHPG, 100 nM/5 μL, i.c.v.) in male Sprague-Dawley rats.Animal Model:Male Swiss mice (25-35 g)
Dosage:3-30 nmol/site (i.t.), 1-10 μmol/paw(i.pl.) and 1-10 nmol/ site (i.c.v.)
Administration:Single injection
Result:The maximal inhibition values for the antinociceptive action of E4CPG in glutamate-induced nociception were 48% (i.pl.), 49% (i.t.) and 40% (i.c.v.).
Animal Model:Male Sprague-Dawley rats
Dosage:35 nM/3.5 μL
Administration:Single injection, i.c.v.
Result:Completely blocked LTD induced by the group I mGluR agonist dihydroxyphenylglycine (DHPG).
体外研究：
E4CPG acts at rat cortical mGluR with the KB value of 0.367 mM.
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