产品
编 号：F205115
分子式：C24H24Cl2N4O4
分子量：503.38
分子式：C24H24Cl2N4O4
分子量：503.38
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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50mg
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结构图
CAS No: 1707289-21-1
产品详情
生物活性：
Fisogatinib (BLU-554) is a potent, highly selective and orally active fibroblast growth factor receptor 4 (FGFR4) inhibitor with an IC50 of 5 nM. Fisogatinib has significant anti-tumor activity in models of hepatocellular carcinoma (HCC) that are dependent on FGFR4 signalling.
体内研究：
Tissue distribution of Fisogatinib (10 mg/kg; oral gavage; for 4 hours; FVB/NRj mice) in wild-type mice is as follows; tissue concentrations decreases in the order liver > kidney > small intestine > spleen > brain. The high Fisogatinib liver-to-plasma ratio suggests there is a relatively high amount of the drug being transported into the liver.Animal Model:Wild type male mice(FVB/NRj, 11-14?weeks of age)
Dosage:10?mg/kg
Administration:Oral gavage; for 4 hours (Pharmacokinetic study)
Result:Tissue concentrations decreased in the order liver?>?kidney?>?small intestine?>?spleen?>?brain.
Fisogatinib (BLU-554) is a potent, highly selective and orally active fibroblast growth factor receptor 4 (FGFR4) inhibitor with an IC50 of 5 nM. Fisogatinib has significant anti-tumor activity in models of hepatocellular carcinoma (HCC) that are dependent on FGFR4 signalling.
体内研究：
Tissue distribution of Fisogatinib (10 mg/kg; oral gavage; for 4 hours; FVB/NRj mice) in wild-type mice is as follows; tissue concentrations decreases in the order liver > kidney > small intestine > spleen > brain. The high Fisogatinib liver-to-plasma ratio suggests there is a relatively high amount of the drug being transported into the liver.Animal Model:Wild type male mice(FVB/NRj, 11-14?weeks of age)
Dosage:10?mg/kg
Administration:Oral gavage; for 4 hours (Pharmacokinetic study)
Result:Tissue concentrations decreased in the order liver?>?kidney?>?small intestine?>?spleen?>?brain.
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