产品
编 号：F204563
分子式：C25H27F2N5O3S
分子量：515.58
分子式：C25H27F2N5O3S
分子量：515.58
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CAS No: 1705602-02-3
产品详情
生物活性：
GNE-4997 is a potent and selective interleukin-2-inducible T-cell kinase (ITK) inhibitor with a Ki of 0.09 nM, and the correlation between the basicity of solubilizing elements in GNE-4997 and off-target antiproliferative effects reduces cytotoxicity.
体外研究：
GNE-4997 inhibits PLC-γ phosphorylation in Jurkat cells by T-cell receptor stimulation with an IC50 of 4 nM .
GNE-4997 is a potent and selective interleukin-2-inducible T-cell kinase (ITK) inhibitor with a Ki of 0.09 nM, and the correlation between the basicity of solubilizing elements in GNE-4997 and off-target antiproliferative effects reduces cytotoxicity.
体外研究：
GNE-4997 inhibits PLC-γ phosphorylation in Jurkat cells by T-cell receptor stimulation with an IC50 of 4 nM .
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