产品
编 号：F203972
分子式：C36H37ClN4O3
分子量：609.16
分子式：C36H37ClN4O3
分子量：609.16
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 170365-25-0
产品详情
生物活性：
KW-8232 free base, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2.
体内研究：
KW-8232 (3, 10, 30 mg/kg, p.o.) potently increases the femoral bone mineral density (BMD) of immobilized legs of rats, and affects immobilization-induced abnormal bone turnovrer. KW-8232 markedly decreases urinary calcium excreation in the neurectomized rats only at 30 mg/kg, and highly reduces urinary pyridinoline and deoxypyridionline excretion which are markers of bone resorption in neurectomized rats. KW-8232 inhibits bone loss may be attributed to the lower prostaglandins (PGs)-stimulated bone resorption via regulation of PGE2 production.Animal Model:male Sprague-Dawley rats (5-week-old).
Dosage:1, 3, 10, and 30 mg/kg.
Administration:Orally once daily beginning 1 day prior to neurectomy for 28 days.
Result:Decreased urinary calcium excreation in the neurectomized rats only at 30 mg/kg.
体外研究：
KW-8232 is an anti-osteoporotic agent. KW-8232 reduces the biosynthesis of PGE2 in mouse osteoblastic cells.KW-8232 possesses anti-viral activity against SARS-CoV-2 (EC50 ~1.2 μM ).
KW-8232 free base, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2.
体内研究：
KW-8232 (3, 10, 30 mg/kg, p.o.) potently increases the femoral bone mineral density (BMD) of immobilized legs of rats, and affects immobilization-induced abnormal bone turnovrer. KW-8232 markedly decreases urinary calcium excreation in the neurectomized rats only at 30 mg/kg, and highly reduces urinary pyridinoline and deoxypyridionline excretion which are markers of bone resorption in neurectomized rats. KW-8232 inhibits bone loss may be attributed to the lower prostaglandins (PGs)-stimulated bone resorption via regulation of PGE2 production.Animal Model:male Sprague-Dawley rats (5-week-old).
Dosage:1, 3, 10, and 30 mg/kg.
Administration:Orally once daily beginning 1 day prior to neurectomy for 28 days.
Result:Decreased urinary calcium excreation in the neurectomized rats only at 30 mg/kg.
体外研究：
KW-8232 is an anti-osteoporotic agent. KW-8232 reduces the biosynthesis of PGE2 in mouse osteoblastic cells.KW-8232 possesses anti-viral activity against SARS-CoV-2 (EC50 ~1.2 μM ).
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备