产品
编 号：F203964
分子式：C31H34O5
分子量：486.6
分子式：C31H34O5
分子量：486.6
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 170355-78-9
产品详情
生物活性：
CD2665 is an orally active and selective RAR-β,γ antagonist, with Kd values of 306 nM, 110 nM for RAR-β and RAR-γ, repectively.
体内研究：
CD2665 (0.6 mg/kg; Subcutaneous injection; daily, for 22 days) completely inhibits the overexpression of RARβ mRNA in the brain of alcohol treated mice. CD2665 is a selective retinoid antagonist and elicits the expected maturation delay and growth plate expansion.Animal Model:Mice submitted to 10 months of ethanol consumption.
Dosage:0.6 mg/kg
Administration:Subcutaneous injection; daily, for 22 days.
Result:Decreased brain RARβ mRNA levels (50% relative to control), without any change in RXR β/γ mRNA levels.
Animal Model:Male and female mice (3 weeks).
Dosage:1.6 mg/kg
Administration:Oral gavage/intragastric; daily, for 31 days.
Result:Growth plate closure had largely been prevented in LDE225/antagonist co-treated mice compared with those receiving LDE225 only.
体外研究：
CD2665 (100 nM; 9 days; 3T3 cells) has significant effects on cell growth and differentiation.
CD2665 is an orally active and selective RAR-β,γ antagonist, with Kd values of 306 nM, 110 nM for RAR-β and RAR-γ, repectively.
体内研究：
CD2665 (0.6 mg/kg; Subcutaneous injection; daily, for 22 days) completely inhibits the overexpression of RARβ mRNA in the brain of alcohol treated mice. CD2665 is a selective retinoid antagonist and elicits the expected maturation delay and growth plate expansion.Animal Model:Mice submitted to 10 months of ethanol consumption.
Dosage:0.6 mg/kg
Administration:Subcutaneous injection; daily, for 22 days.
Result:Decreased brain RARβ mRNA levels (50% relative to control), without any change in RXR β/γ mRNA levels.
Animal Model:Male and female mice (3 weeks).
Dosage:1.6 mg/kg
Administration:Oral gavage/intragastric; daily, for 31 days.
Result:Growth plate closure had largely been prevented in LDE225/antagonist co-treated mice compared with those receiving LDE225 only.
体外研究：
CD2665 (100 nM; 9 days; 3T3 cells) has significant effects on cell growth and differentiation.
产品资料
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