产品
编 号：F203949
分子式：C130H220N44O41
分子量：3055.41
分子式：C130H220N44O41
分子量：3055.41
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 17034-35-4
产品详情
生物活性：
Secretin (swine), a neuroendocrine hormone, is the first hormone to be identifie and is secreted by S cells that are localized primarily in the mucosa of the duodenum. Secretin also is a 27-amino acid peptide, which acts on secretin receptors. Secretin is expressed by cells in all mature enteroendocrine cell subsets and can be prompted by fatty acids. Secretin stimulates the secretion of pancreatic water and bicarbonate. Secretin exerts various effects in organs, can be used for the research of digestive system, central nervous system and energy metabolism.
体内研究：
Secretin (swine) (2.5 nM/kg, BW/day, osmotic minipumps, for 1 week) stimulates biliary cell proliferation by regulating expression of microRNA 125b and microRNA let7a in mice.Animal Model:Sct＋/－mice
Dosage:2.5 nM/kg
Administration:2.5 nM/kg, BW/day, osmotic minipumps, for 1 week
Result:Increased in supernatants from cholangiocytes and S cells and in serum and bile following BDL in control mice.Had low IBDM, reduced proliferation, and reduced production of vascular endothelial growth factor A (VEGFA) and nerve growth factor (NGF) in BDL Sct＋/－mice. Regulated VEGF and NGF expression that negatively correlated with microRNA 125b and let7a levels in liver tissue.
体外研究：
Secretin (swine) (10?7M, 10?6M; 24 to 72 h and 7 days) stimulates biliary growth by interaction with secretin receptors (SR) and knockout of SR reduces biliary proliferation by downregulating cAMP dependent signaling.Secretin (10?7M, 10?6M; 24 to 72 h and 7 days) increases the proliferation in human HIBEpiC and large murine cholangiocyte lines.
Secretin (swine), a neuroendocrine hormone, is the first hormone to be identifie and is secreted by S cells that are localized primarily in the mucosa of the duodenum. Secretin also is a 27-amino acid peptide, which acts on secretin receptors. Secretin is expressed by cells in all mature enteroendocrine cell subsets and can be prompted by fatty acids. Secretin stimulates the secretion of pancreatic water and bicarbonate. Secretin exerts various effects in organs, can be used for the research of digestive system, central nervous system and energy metabolism.
体内研究：
Secretin (swine) (2.5 nM/kg, BW/day, osmotic minipumps, for 1 week) stimulates biliary cell proliferation by regulating expression of microRNA 125b and microRNA let7a in mice.Animal Model:Sct＋/－mice
Dosage:2.5 nM/kg
Administration:2.5 nM/kg, BW/day, osmotic minipumps, for 1 week
Result:Increased in supernatants from cholangiocytes and S cells and in serum and bile following BDL in control mice.Had low IBDM, reduced proliferation, and reduced production of vascular endothelial growth factor A (VEGFA) and nerve growth factor (NGF) in BDL Sct＋/－mice. Regulated VEGF and NGF expression that negatively correlated with microRNA 125b and let7a levels in liver tissue.
体外研究：
Secretin (swine) (10?7M, 10?6M; 24 to 72 h and 7 days) stimulates biliary growth by interaction with secretin receptors (SR) and knockout of SR reduces biliary proliferation by downregulating cAMP dependent signaling.Secretin (10?7M, 10?6M; 24 to 72 h and 7 days) increases the proliferation in human HIBEpiC and large murine cholangiocyte lines.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备