产品
编 号：F203686
分子式：C80H102ClN15O14
分子量：1533.21
分子式：C80H102ClN15O14
分子量：1533.21
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CAS No: 170157-13-8
产品详情
生物活性：
Acyline, a GnRH peptide analogue, is a GnRH antagonist that inhibits gonadotropin and testosterone (T) levels.
体内研究：
Acyline (50 μg, s.c., twice daily, 5 days) can result in disruption of vaginal oestrus and reduce uterine weights in female Kiss1?/?and?Gpr54?/??mice, as well as a decrease in LH concentrations of female?Kiss1?/? mice.Acyline (50 μg, s.c., once) can?reduce FSH concentrations?from?pre-acyline 1.51 ng/mL to post-acyline 1.27 ng/mL in male Kiss1?/? mice and from?pre-acyline 2.87 ng/mL to post-acyline 1.95 ng/mL in male Gpr54?/??mice.Animal Model:Female Kiss1?/?and?Gpr54?/??mice
Dosage:50 μg (1 mg/mL in PBS)
Administration:Subcutaneous injection; twice daily; 5 days
Result:12 Kiss1?/??mice left oestrus within 4 days of 13 mice received acyline while only 2 of 17 mice received vehicle left oestrus.?Also, 7 of 8?Gpr54?/??mice received acyline left oestrus compared to 1 of 7 received vehicle.Reduced uterine weights of?Kiss1?/?and?Gpr54?/? mice in treated group compared to the vehicle group, and reduced serum LH concentrations in Kiss1?/? mice.
Acyline, a GnRH peptide analogue, is a GnRH antagonist that inhibits gonadotropin and testosterone (T) levels.
体内研究：
Acyline (50 μg, s.c., twice daily, 5 days) can result in disruption of vaginal oestrus and reduce uterine weights in female Kiss1?/?and?Gpr54?/??mice, as well as a decrease in LH concentrations of female?Kiss1?/? mice.Acyline (50 μg, s.c., once) can?reduce FSH concentrations?from?pre-acyline 1.51 ng/mL to post-acyline 1.27 ng/mL in male Kiss1?/? mice and from?pre-acyline 2.87 ng/mL to post-acyline 1.95 ng/mL in male Gpr54?/??mice.Animal Model:Female Kiss1?/?and?Gpr54?/??mice
Dosage:50 μg (1 mg/mL in PBS)
Administration:Subcutaneous injection; twice daily; 5 days
Result:12 Kiss1?/??mice left oestrus within 4 days of 13 mice received acyline while only 2 of 17 mice received vehicle left oestrus.?Also, 7 of 8?Gpr54?/??mice received acyline left oestrus compared to 1 of 7 received vehicle.Reduced uterine weights of?Kiss1?/?and?Gpr54?/? mice in treated group compared to the vehicle group, and reduced serum LH concentrations in Kiss1?/? mice.
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