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编 号:F002636
分子式:C18H12O6
分子量:324.28
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1mg
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5mg
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生物活性:
Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor. Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals.

体内研究:
Sterigmatocystine (ip; 3 mg/kg once daily for 14 days) inhibits p21WAF1/CIP1.

体外研究:
Sterigmatocystine-induced DNA damage activates the ATM/53-dependent signaling pathway, which contributes to the induction of G2 arrest in GES-1 cells.
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