产品
编 号：F201204
分子式：C22H42N4O8S2
分子量：554.72
分子式：C22H42N4O8S2
分子量：554.72
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
询价
询价
结构图
CAS No: 16816-67-4
产品详情
生物活性：
Pantethine is an orally active lipid-lowering agent. Pantethine has anti-tumor, anti-inflammatory and anti-SARS-COV virus activities. Pantethine is also a neuroprotective agent. Pantethine can be used in the study of Alzheimer's disease, Parkinson's disease, major depression, systemic sclerosis and pantothenate kinase-related neurodegeneration.
体内研究：
Pantethine (1.2 mmol/kg; 灌胃给药; 单剂量) 在大鼠中具有降血脂的作用。Pantethine (750 mg/kg; 腹腔注射; 每天 1 次，连续 4 周) 在原位卵巢癌小鼠中具有抗肿瘤活性。Pantethine (150 mg/kg; 口服; 一天一次连续 6 周) 在系统性硬化 (SSc) 小鼠中减少了氧化和内皮应激标志物相关的皮肤和肺纤维化。Pantethine (15 mg/kg; 在日常饮水中添加，连续两个月) 在生酮饮食的小鼠中能有效恢复由生酮饮食诱导的疾病表征状况。Animal Model:Male Sprague–Dawley rats model
Dosage:1.2 mmol/kg
Administration:Intragastrical administration (i.g.); Single dose
Result:Reduced plasma free fatty acid (FFA), cholesterol, and triglyceride levels at 3, 5, 7, and 24 h, while significantly increased glycerol levels at 7 h.
Animal Model:Orthotopic female rats model of ovarian cancer
Dosage:750 mg/kg
Administration:Intraperitoneal injection (i.p.); Once daily for 4 weeks
Result:Reduced tumor growth, metastasis and ascites, and had no toxicity to liver and kidney.
Animal Model:Systemic sclerosis (SSc) BALB/c mice model
Dosage:15 mg/kg
Administration:Oral gavage (p.o.); Once daily for 6 weeks. After HOCL treatment ( 200 μM; Intradermal injection; Once daiy for 6 weeks).
Result:Decreased the number of MPs in mice endothelial cells.Decreased the concentrations of soluble E-selectin and sVCAM-1 in serum.Decreased serum concentration of AOPPs (33%) and nitrate (60%).
Animal Model:Ketogenic diet mouse model
Dosage:150 mg/kg
Administration:Supplemented in daily drinking water, for 2 months. Follow a casual ketogenic diet during this period.
Result:Alleviated motor dysfunction, neurodegeneration and changes in mitochondria of the central and peripheral nervous systems in mice.
体外研究：
Pantethine (10-1000 μM) 能抑制小鼠肝脏切片中胆固醇的生成。Pantethine (250-1000 μM; 24 h 和 72 h) 降低了 Vero E6 细胞中胆固醇水平 (在处理 24 h时降低 35%， 处理 72 h 降低 80%)。Pantethine (100-1000 μM; 先预处理 1 h，然后加入病毒再共同孵育 2 h，直到实验结束) 以剂量依赖方式降低 SARS?CoV?2 对 Vero E6 和 Calu-3a 细胞的感染，具有抗病毒作用。Pantethine (50-100 μM; 18 h) 在内皮细胞 HPMECs 和 HUVECs 中以剂量依赖方式抑制微粒 (MPs) 的释放。 (50-100 μM; 24 h) 消除了 MP 诱导的内皮细胞 (HPMECs 和 HUVECs) 和成纤维细胞 (NIH3T3) 的氧化和亚硝化应激。
Pantethine is an orally active lipid-lowering agent. Pantethine has anti-tumor, anti-inflammatory and anti-SARS-COV virus activities. Pantethine is also a neuroprotective agent. Pantethine can be used in the study of Alzheimer's disease, Parkinson's disease, major depression, systemic sclerosis and pantothenate kinase-related neurodegeneration.
体内研究：
Pantethine (1.2 mmol/kg; 灌胃给药; 单剂量) 在大鼠中具有降血脂的作用。Pantethine (750 mg/kg; 腹腔注射; 每天 1 次，连续 4 周) 在原位卵巢癌小鼠中具有抗肿瘤活性。Pantethine (150 mg/kg; 口服; 一天一次连续 6 周) 在系统性硬化 (SSc) 小鼠中减少了氧化和内皮应激标志物相关的皮肤和肺纤维化。Pantethine (15 mg/kg; 在日常饮水中添加，连续两个月) 在生酮饮食的小鼠中能有效恢复由生酮饮食诱导的疾病表征状况。Animal Model:Male Sprague–Dawley rats model
Dosage:1.2 mmol/kg
Administration:Intragastrical administration (i.g.); Single dose
Result:Reduced plasma free fatty acid (FFA), cholesterol, and triglyceride levels at 3, 5, 7, and 24 h, while significantly increased glycerol levels at 7 h.
Animal Model:Orthotopic female rats model of ovarian cancer
Dosage:750 mg/kg
Administration:Intraperitoneal injection (i.p.); Once daily for 4 weeks
Result:Reduced tumor growth, metastasis and ascites, and had no toxicity to liver and kidney.
Animal Model:Systemic sclerosis (SSc) BALB/c mice model
Dosage:15 mg/kg
Administration:Oral gavage (p.o.); Once daily for 6 weeks. After HOCL treatment ( 200 μM; Intradermal injection; Once daiy for 6 weeks).
Result:Decreased the number of MPs in mice endothelial cells.Decreased the concentrations of soluble E-selectin and sVCAM-1 in serum.Decreased serum concentration of AOPPs (33%) and nitrate (60%).
Animal Model:Ketogenic diet mouse model
Dosage:150 mg/kg
Administration:Supplemented in daily drinking water, for 2 months. Follow a casual ketogenic diet during this period.
Result:Alleviated motor dysfunction, neurodegeneration and changes in mitochondria of the central and peripheral nervous systems in mice.
体外研究：
Pantethine (10-1000 μM) 能抑制小鼠肝脏切片中胆固醇的生成。Pantethine (250-1000 μM; 24 h 和 72 h) 降低了 Vero E6 细胞中胆固醇水平 (在处理 24 h时降低 35%， 处理 72 h 降低 80%)。Pantethine (100-1000 μM; 先预处理 1 h，然后加入病毒再共同孵育 2 h，直到实验结束) 以剂量依赖方式降低 SARS?CoV?2 对 Vero E6 和 Calu-3a 细胞的感染，具有抗病毒作用。Pantethine (50-100 μM; 18 h) 在内皮细胞 HPMECs 和 HUVECs 中以剂量依赖方式抑制微粒 (MPs) 的释放。 (50-100 μM; 24 h) 消除了 MP 诱导的内皮细胞 (HPMECs 和 HUVECs) 和成纤维细胞 (NIH3T3) 的氧化和亚硝化应激。
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