产品
编 号：F200855
分子式：C16H13NO3
分子量：267.28
分子式：C16H13NO3
分子量：267.28
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
660
In-stock
5mg
600
In-stock
10mg
866
In-stock
50mg
2480
In-stock
100mg
3280
In-stock
200mg
4264
In-stock
结构图
CAS No: 167869-21-8
产品详情
生物活性：
PD98059 is a potent and selective MEK inhibitor with an IC50 of 5 μM. PD98059 binds to the inactive form of MEK, thereby preventing the activation of MEK1 (IC50 of 2-7 μM) and MEK2 (IC50 of 50 μM) by upstream kinases. PD98059 is a ERK1/2 signaling inhibitor. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR), and suppresses TCDD binding (IC50 of 4 μM) and AHR transformation (IC50 of 1 μM). PD98059 also inhibits Mycobacterium bovis Bacillus CalmetteGuerin (BCG)-induced autophagy.
体内研究：
PD98059 (10 mg/kg；腹腔注射；在酵母聚糖后 1 和 6 小时) 显著降低注射酵母聚糖的小鼠中的 p-ERK1/2 水平。Animal Model:Male CD mice
Dosage:10 mg/kg
Administration:Intraperitoneal injection; 1 and 6 hours after Zymosan
Result:Significantly reduced the level of p-ERK1/2.
体外研究：
PD98059 (20 μM；24 小时) 导致 OCI-AML-3 细胞 G1 期细胞周期停滞。 PD98059 (10 μM；22 小时) 导致浓度依赖性ERK1 和 ERK2 双磷酸化形式的减少。PD98059 既可防止 ERK 激活，又可阻断 TDP-43 和 HuR 阳性 SGs 的形成。
PD98059 is a potent and selective MEK inhibitor with an IC50 of 5 μM. PD98059 binds to the inactive form of MEK, thereby preventing the activation of MEK1 (IC50 of 2-7 μM) and MEK2 (IC50 of 50 μM) by upstream kinases. PD98059 is a ERK1/2 signaling inhibitor. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR), and suppresses TCDD binding (IC50 of 4 μM) and AHR transformation (IC50 of 1 μM). PD98059 also inhibits Mycobacterium bovis Bacillus CalmetteGuerin (BCG)-induced autophagy.
体内研究：
PD98059 (10 mg/kg；腹腔注射；在酵母聚糖后 1 和 6 小时) 显著降低注射酵母聚糖的小鼠中的 p-ERK1/2 水平。Animal Model:Male CD mice
Dosage:10 mg/kg
Administration:Intraperitoneal injection; 1 and 6 hours after Zymosan
Result:Significantly reduced the level of p-ERK1/2.
体外研究：
PD98059 (20 μM；24 小时) 导致 OCI-AML-3 细胞 G1 期细胞周期停滞。 PD98059 (10 μM；22 小时) 导致浓度依赖性ERK1 和 ERK2 双磷酸化形式的减少。PD98059 既可防止 ERK 激活，又可阻断 TDP-43 和 HuR 阳性 SGs 的形成。
产品资料
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