产品
编 号：F200301
分子式：C20H19ClN2O3
分子量：370.83
分子式：C20H19ClN2O3
分子量：370.83
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 1672684-68-2
产品详情
生物活性：
MS402 is a BD1-selective BET BrD inhibitor with Kis of 77 nM, 718 nM, 110 nM, 200 nM, 83 nM, and 240 nM for BRD4(BD1), BRD4(BD2), BRD3(BD1), BRD3(BD2), BRD2(BD1) and BRD2(BD2), respectively. MS402 blocks Th17 cell differentiation and ameliorates colitis in mice.
体内研究：
Reconstitution with na?ve CD4+CD45RBhi cells isolated from spleen and lymph nodes of C57BL/6 mice, Rag1-/- mice begin losing weight after 4 week. MS402 (10 mg/kg; intraperitoneally twice a week for 3 weeks) shows much less weight loss.Animal Model:C57BL/6 mice, Rag1-/- mice with T-cell transfer-induced colitis model
Dosage:10 mg/kg
Administration:Intraperitoneally twice a week for 3 weeks
Result:Showed much less weight loss.
MS402 is a BD1-selective BET BrD inhibitor with Kis of 77 nM, 718 nM, 110 nM, 200 nM, 83 nM, and 240 nM for BRD4(BD1), BRD4(BD2), BRD3(BD1), BRD3(BD2), BRD2(BD1) and BRD2(BD2), respectively. MS402 blocks Th17 cell differentiation and ameliorates colitis in mice.
体内研究：
Reconstitution with na?ve CD4+CD45RBhi cells isolated from spleen and lymph nodes of C57BL/6 mice, Rag1-/- mice begin losing weight after 4 week. MS402 (10 mg/kg; intraperitoneally twice a week for 3 weeks) shows much less weight loss.Animal Model:C57BL/6 mice, Rag1-/- mice with T-cell transfer-induced colitis model
Dosage:10 mg/kg
Administration:Intraperitoneally twice a week for 3 weeks
Result:Showed much less weight loss.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备