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编 号：F023925
分子式：C21H19ClF3N3O3
分子量：453.84
分子式：C21H19ClF3N3O3
分子量：453.84
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CAS No: 105784-61-0
产品详情
生物活性：
Temafloxacin (TMFX) hydrochloride is an orally active quinolone broad-spectrum antibacterial agent. Temafloxacin hydrochloride is well tolerated in lower respiratory and genitourinary tract infections.
体内研究：
Temafloxacin hydrochloride (6.25, 25, 100 mg/kg; p.o.; single) shows good inhibitory activity to murine pyelonephritis.Temafloxacin hydrochloride (100 mg/kg; p.o. or s.c.; single) shows rapid gastrointestinal absorption, and has excellent tissue and body fluid penetration and concentration (except for central nervous system (CNS)).Animal Model:Female CF-1 mice (20-25 g) (murine pyelonephritis model).
Dosage:6.25, 25, 100 mg/kg
Administration:Orally; single.
Result:Reduced the number of viable bacteria in the kidneys of mice.
Animal Model:Female CF-1 mice (20-25 g).
Dosage:100 mg/kg
Administration:Subcutaneously or orally; single.
Result:1.19Pharmacokinetic Parameters of Temafloxacin hydrochloride in Female CF-1 mice.Cmax (μg/mL)AUC (μg/mL?h)T1/2 (h)% Urinary recovery
SC (100 mg/kg)25.286.63.425.3
PO (100 mg/kg)13.557.41.39.1
体外研究：
Temafloxacin hydrochloride (0-64 μg/mL; 18-24 h) shows good antibacterial activity for gram-positive/negative bacteria, with MIC ranges of Temafloxacin hydrochloride 相关抗体:Cell Viability AssayCell Line:E. coli (16 strains), P. aeruginosa (13 strains), and S. aureus (17 strains)
Concentration:0-64 μg/mL
Incubation Time:18-24 h
Result:Inhibited E. coli (16 strains), P. aeruginosa, and S. aureus with MIC ranges of <0.004-0.5 (MIC 90%=0.06, =0.06), 0.5-2 (MIC 90%=1, MIC 50%=1) and 0.06-0.25 μg/mL (MIC 90%=0.125, MIC 50%=0.125). MIC 90% and 50% means MIC for 90% and 50% of the isolates (unit: μg/mL).
Temafloxacin (TMFX) hydrochloride is an orally active quinolone broad-spectrum antibacterial agent. Temafloxacin hydrochloride is well tolerated in lower respiratory and genitourinary tract infections.
体内研究：
Temafloxacin hydrochloride (6.25, 25, 100 mg/kg; p.o.; single) shows good inhibitory activity to murine pyelonephritis.Temafloxacin hydrochloride (100 mg/kg; p.o. or s.c.; single) shows rapid gastrointestinal absorption, and has excellent tissue and body fluid penetration and concentration (except for central nervous system (CNS)).Animal Model:Female CF-1 mice (20-25 g) (murine pyelonephritis model).
Dosage:6.25, 25, 100 mg/kg
Administration:Orally; single.
Result:Reduced the number of viable bacteria in the kidneys of mice.
Animal Model:Female CF-1 mice (20-25 g).
Dosage:100 mg/kg
Administration:Subcutaneously or orally; single.
Result:1.19Pharmacokinetic Parameters of Temafloxacin hydrochloride in Female CF-1 mice.Cmax (μg/mL)AUC (μg/mL?h)T1/2 (h)% Urinary recovery
SC (100 mg/kg)25.286.63.425.3
PO (100 mg/kg)13.557.41.39.1
体外研究：
Temafloxacin hydrochloride (0-64 μg/mL; 18-24 h) shows good antibacterial activity for gram-positive/negative bacteria, with MIC ranges of Temafloxacin hydrochloride 相关抗体:Cell Viability AssayCell Line:E. coli (16 strains), P. aeruginosa (13 strains), and S. aureus (17 strains)
Concentration:0-64 μg/mL
Incubation Time:18-24 h
Result:Inhibited E. coli (16 strains), P. aeruginosa, and S. aureus with MIC ranges of <0.004-0.5 (MIC 90%=0.06, =0.06), 0.5-2 (MIC 90%=1, MIC 50%=1) and 0.06-0.25 μg/mL (MIC 90%=0.125, MIC 50%=0.125). MIC 90% and 50% means MIC for 90% and 50% of the isolates (unit: μg/mL).
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