产品
编 号：F023811
分子式：C21H21F3N4O
分子量：402.41
分子式：C21H21F3N4O
分子量：402.41
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
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5mg
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10mg
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25mg
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结构图
CAS No: 1057394-06-5
产品详情
生物活性：
AL 8697 is a specific and orally active p38α MAPK inhibitor with an IC50 of 6 nM. AL 8697 displays 14-fold greater inhibition of p38α compared to p38β (IC50=82 nM), and 300-fold selectivity for p38α over a panel of 91 kinases. Anti-inflammatory activity.
体内研究：
AL 8697 (1-30 mg/kg; p.o.; once daily for 10 days) dose-dependently decreases the oedema in right and left paws.Animal Model:Male Wistar rats
Dosage:1, 3, 10, 30 mg/kg
Administration:Oral gavage; once daily for 10 days
Result:Dose-dependently decreased the oedema in right and left paws, causing a larger improvement in the contralateral un-injected paw.
AL 8697 is a specific and orally active p38α MAPK inhibitor with an IC50 of 6 nM. AL 8697 displays 14-fold greater inhibition of p38α compared to p38β (IC50=82 nM), and 300-fold selectivity for p38α over a panel of 91 kinases. Anti-inflammatory activity.
体内研究：
AL 8697 (1-30 mg/kg; p.o.; once daily for 10 days) dose-dependently decreases the oedema in right and left paws.Animal Model:Male Wistar rats
Dosage:1, 3, 10, 30 mg/kg
Administration:Oral gavage; once daily for 10 days
Result:Dose-dependently decreased the oedema in right and left paws, causing a larger improvement in the contralateral un-injected paw.
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