产品
编 号：F199044
分子式：C12H11ClN2O2S
分子量：282.75
分子式：C12H11ClN2O2S
分子量：282.75
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 165682-93-9
产品详情
生物活性：
O4I2 is a potent Oct3/4 inducer. O4I2 induces the expression of pluripotent-associated genes Lin28, Sox2 and Nanog, and suppresses Rex1.
体外研究：
O4I2 not only promotes Oct3/4 expression by activating its promoter site, but also stabilize the Oct3/4 protein in HEK293 cells.O4I2 markedly stimulates Oct3/4 even at 5 μM after 72 hrs treatment on the translationallevel.O4I2 (20 μM) accumulates Oct3/4 in NCCIT occurred already 2 hrs after incubation, while the detectable Sox2 increase appears much later, implicating compound-mediated activation of Oct3/4 might be different between embryonic kidney HEK293 cells and embryonal carcinoma NCCIT cells.
O4I2 is a potent Oct3/4 inducer. O4I2 induces the expression of pluripotent-associated genes Lin28, Sox2 and Nanog, and suppresses Rex1.
体外研究：
O4I2 not only promotes Oct3/4 expression by activating its promoter site, but also stabilize the Oct3/4 protein in HEK293 cells.O4I2 markedly stimulates Oct3/4 even at 5 μM after 72 hrs treatment on the translationallevel.O4I2 (20 μM) accumulates Oct3/4 in NCCIT occurred already 2 hrs after incubation, while the detectable Sox2 increase appears much later, implicating compound-mediated activation of Oct3/4 might be different between embryonic kidney HEK293 cells and embryonal carcinoma NCCIT cells.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备