产品
编 号：F198108
分子式：C14H13ClF6N6
分子量：414.74
分子式：C14H13ClF6N6
分子量：414.74
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
2mg
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5mg
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10mg
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50mg
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结构图
CAS No: 1644545-52-7
产品详情
生物活性：
Vorasidenib (AG-881) is an orally available, brain penetrant second-generation dual mutant isocitrate dehydrogenases 1 and 2 (mIDH1/2) inhibitor. Vorasidenib (AG-881) exhibits nanomolar inhibition of (D)-2-hydroxyglutarate (D-2-HG), and the IC50 ranges of 0.04~22 nM against IDH1 R132C, IDH1 R132G, IDH1 R132H and IDH1 R132S and 7~14 nM against IDH2 R140Q and 130 nM against IDH2 R172K.
体外研究：
Vorasidenib 对人胶质母细胞瘤 U-87 MG pLVX-IDH2 R140Q-neo、纤维肉瘤 HT-1080 和神经球 TS603 细胞具有很强的抗增殖活性，IC50 均小于 50 nM。
Vorasidenib (AG-881) is an orally available, brain penetrant second-generation dual mutant isocitrate dehydrogenases 1 and 2 (mIDH1/2) inhibitor. Vorasidenib (AG-881) exhibits nanomolar inhibition of (D)-2-hydroxyglutarate (D-2-HG), and the IC50 ranges of 0.04~22 nM against IDH1 R132C, IDH1 R132G, IDH1 R132H and IDH1 R132S and 7~14 nM against IDH2 R140Q and 130 nM against IDH2 R172K.
体外研究：
Vorasidenib 对人胶质母细胞瘤 U-87 MG pLVX-IDH2 R140Q-neo、纤维肉瘤 HT-1080 和神经球 TS603 细胞具有很强的抗增殖活性，IC50 均小于 50 nM。
产品资料
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