产品
编 号：F197651
分子式：C13H13Cl3N4
分子量：331.63
分子式：C13H13Cl3N4
分子量：331.63
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规格
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结构图
CAS No: 1640282-30-9
产品详情
生物活性：
TH588 hydrochloride is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 (IC50= 5 nM).
体内研究：
TH588 (30 mg/kg; s.c.; once daily for 35 days) reduces tumour growth in SW480 xenograft cancer model.Animal Model:5-6 weeks female SCID mice (SW480 xenograft cancer model)
Dosage:30 mg/kg
Administration:Subcutaneous injection (s.c.); once daily for 35 days
Result:Reduced tumour growth in SW480 xenograft cancer model.
体外研究：
TH588 (2-10μM; 7-10 days) selectively and effectively kills U2OS, HeLa, MDA-MB-231, MCF-7, SW480, and SW620 cells with IC50s of 1.38, 0.83, 1.03, 1.08, 1.72, 0.8 μM .
TH588 hydrochloride is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 (IC50= 5 nM).
体内研究：
TH588 (30 mg/kg; s.c.; once daily for 35 days) reduces tumour growth in SW480 xenograft cancer model.Animal Model:5-6 weeks female SCID mice (SW480 xenograft cancer model)
Dosage:30 mg/kg
Administration:Subcutaneous injection (s.c.); once daily for 35 days
Result:Reduced tumour growth in SW480 xenograft cancer model.
体外研究：
TH588 (2-10μM; 7-10 days) selectively and effectively kills U2OS, HeLa, MDA-MB-231, MCF-7, SW480, and SW620 cells with IC50s of 1.38, 0.83, 1.03, 1.08, 1.72, 0.8 μM .
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