产品
编 号：F197466
分子式：C22H25ClO7
分子量：436.88
分子式：C22H25ClO7
分子量：436.88
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 1638851-44-1
产品详情
生物活性：
HSK0935 is a potent, highly selective and orally available SGLT2 inhibitor with an IC50 of 1.3 nM. Antihyperglycemic activities.
体内研究：
HSK0935 treatment (1, 3, and 10 mg/kg) shows robust urinary glucose excretion in Sprague?Dawley (SD) rats and affects more urinary glucose excretion in Rhesus monkeys.HSK0935 is well tolerated up to 300 mg/kg without any mortality or severe untoward effects in a 28-day repeat-dose toxicology study in beagle dogs.
体外研究：
HSK0935 (Compound 31) demonstrates excellent hSGLT2 inhibition of 1.3 nM and a high hSGLT1/hSGLT2 selectivity of 843-fold.
HSK0935 is a potent, highly selective and orally available SGLT2 inhibitor with an IC50 of 1.3 nM. Antihyperglycemic activities.
体内研究：
HSK0935 treatment (1, 3, and 10 mg/kg) shows robust urinary glucose excretion in Sprague?Dawley (SD) rats and affects more urinary glucose excretion in Rhesus monkeys.HSK0935 is well tolerated up to 300 mg/kg without any mortality or severe untoward effects in a 28-day repeat-dose toxicology study in beagle dogs.
体外研究：
HSK0935 (Compound 31) demonstrates excellent hSGLT2 inhibition of 1.3 nM and a high hSGLT1/hSGLT2 selectivity of 843-fold.
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