产品
编 号：F197059
分子式：C17H19ClN2O4S
分子量：382.86
分子式：C17H19ClN2O4S
分子量：382.86
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 1638611-48-9
产品详情
生物活性：
JC124 is a specific NLRP3 inflammasome inhibitor. JC124 has anti-inflammatory and neuroprotective effects.
体内研究：
JC124 (100?mg/kg; i.p.; 4 doses; 30?min post-injury, 6, 24, and 30?h after TBI) treatment significantly decreases the number of injury-induced degenerating neurons, inflammatory cell response in the injured brain, and cortical lesion volume. JC124 also significantly reduces protein expression levels of NLRP3, ASC, IL-1 beta, TNFα, iNOS, and caspase-1.Animal Model:Adult male Sprague-Dawley rats (3-4-months-old) bearing traumatic brain injury (TBI)
Dosage:100?mg/kg
Administration:i.p.; 4 doses; 30?min post-injury, 6, 24, and 30?h after TBI
Result:Significantly decreased the number of injury-induced degenerating neurons, inflammatory cell response in the injured brain, and cortical lesion volume.
体外研究：
JC124 shows selective inhibition of NLRP3 inflammasome formation and activation of caspase-1, and reduction of IL-1β both in vitro.
JC124 is a specific NLRP3 inflammasome inhibitor. JC124 has anti-inflammatory and neuroprotective effects.
体内研究：
JC124 (100?mg/kg; i.p.; 4 doses; 30?min post-injury, 6, 24, and 30?h after TBI) treatment significantly decreases the number of injury-induced degenerating neurons, inflammatory cell response in the injured brain, and cortical lesion volume. JC124 also significantly reduces protein expression levels of NLRP3, ASC, IL-1 beta, TNFα, iNOS, and caspase-1.Animal Model:Adult male Sprague-Dawley rats (3-4-months-old) bearing traumatic brain injury (TBI)
Dosage:100?mg/kg
Administration:i.p.; 4 doses; 30?min post-injury, 6, 24, and 30?h after TBI
Result:Significantly decreased the number of injury-induced degenerating neurons, inflammatory cell response in the injured brain, and cortical lesion volume.
体外研究：
JC124 shows selective inhibition of NLRP3 inflammasome formation and activation of caspase-1, and reduction of IL-1β both in vitro.
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