产品
编 号：F196880
分子式：C40H67N5O8
分子量：745.99
分子式：C40H67N5O8
分子量：745.99
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 163768-50-1
产品详情
生物活性：
Auristatin F is a potent cytotoxin in antibo-conjugated agents and an analogue of MMAF. Auristatin F is a potent microtubule inhibitor and vascular damaging agent (VDA). Auristatin F inhibits cell division by preventing tubulin aggregation.Auristatin F can be used in antibody-drug conjugates (ADC) .
体内研究：
Auristatin F (5 mg/kg; i.v.; male Sprague-Dawley rats) has Cmax of 8276.76 ng/mL. The AUClast is 65661.30 min*ng/mL, and the clearance (CL) is 77.33 mL/min/kg, which is above the hepatic blood flow in the rat.Animal Model:Male Sprague-Dawley rats
Dosage:5 mg/kg
Administration:Intravenous injection
Result:1.19Parameter
Dose (i.v.) mg/kg5
Cmax (ng/mL)8276.76
AUClast (min*ng/mL)62661.30
CL (mL/min/ng)77.33
Vss (mL/Kg)1057.13
体外研究：
Auristatin F and Monomethyl Auristatin F (MMAF) are potent ADC cytotoxin used in antibody-drug conjugates.
Auristatin F is a potent cytotoxin in antibo-conjugated agents and an analogue of MMAF. Auristatin F is a potent microtubule inhibitor and vascular damaging agent (VDA). Auristatin F inhibits cell division by preventing tubulin aggregation.Auristatin F can be used in antibody-drug conjugates (ADC) .
体内研究：
Auristatin F (5 mg/kg; i.v.; male Sprague-Dawley rats) has Cmax of 8276.76 ng/mL. The AUClast is 65661.30 min*ng/mL, and the clearance (CL) is 77.33 mL/min/kg, which is above the hepatic blood flow in the rat.Animal Model:Male Sprague-Dawley rats
Dosage:5 mg/kg
Administration:Intravenous injection
Result:1.19Parameter
Dose (i.v.) mg/kg5
Cmax (ng/mL)8276.76
AUClast (min*ng/mL)62661.30
CL (mL/min/ng)77.33
Vss (mL/Kg)1057.13
体外研究：
Auristatin F and Monomethyl Auristatin F (MMAF) are potent ADC cytotoxin used in antibody-drug conjugates.
产品资料
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