产品
编 号：F196300
分子式：C24H25F3N4O2
分子量：458.48
分子式：C24H25F3N4O2
分子量：458.48
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 1632236-44-2
产品详情
生物活性：
KLH45 is a potent and selective DDHD2 inhibitor, with an IC50 of 1.3 nM.
体内研究：
KLH45 (20 mg/kg; administered every 12 h) for a total of 4 d exhibits significant elevations in several of the TAGs that accumulated in the brains of DDHD2?/? mice.Animal Model:Mice.
Dosage:5-40 mg/kg.
Administration:IP, once.
Result:Did not show altered brain TAGs.
体外研究：
KLH45 (25 nM, 4 h) completely inactivats DDHD2 (>95% inhibition) in Neuro2A cells and shows no cross-reactivity with any of the other 40+ detected serine hydrolases with the exception of ABHD6.KLH45 (2 μM) increases LD formation in fatty acid-supplemented DDHD2-expressing cells.
KLH45 is a potent and selective DDHD2 inhibitor, with an IC50 of 1.3 nM.
体内研究：
KLH45 (20 mg/kg; administered every 12 h) for a total of 4 d exhibits significant elevations in several of the TAGs that accumulated in the brains of DDHD2?/? mice.Animal Model:Mice.
Dosage:5-40 mg/kg.
Administration:IP, once.
Result:Did not show altered brain TAGs.
体外研究：
KLH45 (25 nM, 4 h) completely inactivats DDHD2 (>95% inhibition) in Neuro2A cells and shows no cross-reactivity with any of the other 40+ detected serine hydrolases with the exception of ABHD6.KLH45 (2 μM) increases LD formation in fatty acid-supplemented DDHD2-expressing cells.
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