产品
编 号：F195771
分子式：C20H31N3O
分子量：329.48
分子式：C20H31N3O
分子量：329.48
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 1629138-41-5
产品详情
生物活性：
SRI-011381 is an orally active TGF-β signaling agonist, exhibits neuroprotective effects.
体内研究：
SRI-011381 (30 mg/kg；腹腔注射；每 2 天一次；持续 22 天) 部分修复 YAPGFAP-CKO EAE 小鼠的视神经和视网膜缺陷。Animal Model:YAPGFAP-CKO mice bearing experimental autoimmune encephalomyelitis (EAE)
Dosage:30 mg/kg
Administration:Intraperitoneally injection; every 2 d; for 22 days
Result:Significantly inhibited inflammatory infiltration and relieved the loss of neurons in YAPGFAP-CKO EAE mice.
体外研究：
SRI-011381 (10 μM) 促进小鼠肺成纤维细胞增殖，显着增加 TGF-β1、NALP3、collagen-1、α-SMA 表达。
SRI-011381 is an orally active TGF-β signaling agonist, exhibits neuroprotective effects.
体内研究：
SRI-011381 (30 mg/kg；腹腔注射；每 2 天一次；持续 22 天) 部分修复 YAPGFAP-CKO EAE 小鼠的视神经和视网膜缺陷。Animal Model:YAPGFAP-CKO mice bearing experimental autoimmune encephalomyelitis (EAE)
Dosage:30 mg/kg
Administration:Intraperitoneally injection; every 2 d; for 22 days
Result:Significantly inhibited inflammatory infiltration and relieved the loss of neurons in YAPGFAP-CKO EAE mice.
体外研究：
SRI-011381 (10 μM) 促进小鼠肺成纤维细胞增殖，显着增加 TGF-β1、NALP3、collagen-1、α-SMA 表达。
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