产品
编 号：F023167
分子式：C22H25N3O3
分子量：379.45
分子式：C22H25N3O3
分子量：379.45
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 1054-88-2
产品详情
生物活性：
Spiroxatrine (R 5188) is a selective, dual antagonist of 5-HT1α and α2-adrenergic, with the Ki values of 3.94, 224000, 118.5 nM for 5-HT1α, 5-HT1β and 5-HT2, respectively. Spiroxatrine (R 5188) has a sedative effect.
体内研究：
Spiroxatrine (1-25 ug, 腹腔注射, 5 天) 增加神经损伤大鼠和 Carrageenan (HY-125474) 诱导的炎症大鼠后爪对热刺激和机械刺激的戒断潜伏期。Spiroxatrine (4 mg/kg/每天, 腹腔注射, 5 分钟) 增强 Fluoxetine (HY-B0102) 减少选择性繁殖的嗜醇性 P系大鼠自愿口服乙醇摄入的效果。Animal Model:The nerve injury rat model and Carrageenan (HY-125474)-induced rat inflammation model
Dosage:1, 10, 25 ug, 5 days
Administration:Intraperitoneal injection (i.p.)
Result:Increased hindpaw withdrawal latencies to thermal and mechanical stimulation.
Animal Model:Fluoxetine (HY-B0102) -induced reduction of ethanol Intake by the P Line of rats
Dosage:4 mg/kg/day, 5 mins
Administration:Intraperitoneal injection (i.p.)
Result:Increased the voluntary oral ethanol intake induced by Fluoxetine (HY-B0102) in the selectively bred alcohol-preferring P line of rats.
体外研究：
Spiroxatrine (0.01-0.1 μM, 15 mins) 使 α2A/D-肾上腺素受体敲除小鼠输精管组织收缩增强。
Spiroxatrine (R 5188) is a selective, dual antagonist of 5-HT1α and α2-adrenergic, with the Ki values of 3.94, 224000, 118.5 nM for 5-HT1α, 5-HT1β and 5-HT2, respectively. Spiroxatrine (R 5188) has a sedative effect.
体内研究：
Spiroxatrine (1-25 ug, 腹腔注射, 5 天) 增加神经损伤大鼠和 Carrageenan (HY-125474) 诱导的炎症大鼠后爪对热刺激和机械刺激的戒断潜伏期。Spiroxatrine (4 mg/kg/每天, 腹腔注射, 5 分钟) 增强 Fluoxetine (HY-B0102) 减少选择性繁殖的嗜醇性 P系大鼠自愿口服乙醇摄入的效果。Animal Model:The nerve injury rat model and Carrageenan (HY-125474)-induced rat inflammation model
Dosage:1, 10, 25 ug, 5 days
Administration:Intraperitoneal injection (i.p.)
Result:Increased hindpaw withdrawal latencies to thermal and mechanical stimulation.
Animal Model:Fluoxetine (HY-B0102) -induced reduction of ethanol Intake by the P Line of rats
Dosage:4 mg/kg/day, 5 mins
Administration:Intraperitoneal injection (i.p.)
Result:Increased the voluntary oral ethanol intake induced by Fluoxetine (HY-B0102) in the selectively bred alcohol-preferring P line of rats.
体外研究：
Spiroxatrine (0.01-0.1 μM, 15 mins) 使 α2A/D-肾上腺素受体敲除小鼠输精管组织收缩增强。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备