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编 号：F195500
分子式：C52H88N10O15
分子量：1093.31
分子式：C52H88N10O15
分子量：1093.31
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CAS No: 162808-62-0
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生物活性：
Caspofungin is a potent antifungal agent. Caspofungin inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan.
体内研究：
Caspofungin (1-8 mg/kg; i.p.; daily, for 7 days) is able to penetrate the CNS in mice and achieve concentrations that result in the reduction of Candida burden in the brain.Caspofungin (0.41-41 μM; i.p.; for 5 weeks; male C57BL/6 mice) is a safe antifungal agent at vitreal concentrations of 0.41 to 4.1 μM in mice.Animal Model:Complement component 5-deficient DBA/2N mice
Dosage:1, 2, 4 and 8 mg/kg
Administration:Intraperitoneal injection; daily, for 7 days.
Result:Reduced the concentration of Candida load in the brain.
Animal Model:Male C57BL/6 mice
Dosage:0.41, 1.2, 2.5, 4.1, and 41 μM
Administration:Intraperitoneal injection; for 5 weeks
Result:Had nonsignificant alterations in their ERG waveforms from 0.41 to 4.1 μM.
Caspofungin is a potent antifungal agent. Caspofungin inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan.
体内研究：
Caspofungin (1-8 mg/kg; i.p.; daily, for 7 days) is able to penetrate the CNS in mice and achieve concentrations that result in the reduction of Candida burden in the brain.Caspofungin (0.41-41 μM; i.p.; for 5 weeks; male C57BL/6 mice) is a safe antifungal agent at vitreal concentrations of 0.41 to 4.1 μM in mice.Animal Model:Complement component 5-deficient DBA/2N mice
Dosage:1, 2, 4 and 8 mg/kg
Administration:Intraperitoneal injection; daily, for 7 days.
Result:Reduced the concentration of Candida load in the brain.
Animal Model:Male C57BL/6 mice
Dosage:0.41, 1.2, 2.5, 4.1, and 41 μM
Administration:Intraperitoneal injection; for 5 weeks
Result:Had nonsignificant alterations in their ERG waveforms from 0.41 to 4.1 μM.
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