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编 号：F195300
分子式：C18H14O5
分子量：310.3
分子式：C18H14O5
分子量：310.3
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CAS No: 16265-56-8
产品详情
生物活性：
6-Deoxyjacareubin is a natural xanthone, that can be isolated from the leaves of Vismia latifolia. 6-Deoxyjacareubin protects against non-apoptotic cell death by inhibiting ROS production. 6-Deoxyjacareubin ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis (ALS).
体内研究：
6-Deoxyjacareubin (5 mg/kg, Intraperitoneally (i.p.), every seven days for 1 month) attenuates motor neuron loss in familial ALS model mice.Animal Model:Male SOD1G93A mice (eight weeks)
Dosage:5 mg/kg
Administration:Intraperitoneally (i.p.), every seven days for 1 month
Result:Prolonged the survival time of SOD1G93A mice and improved their locomotor dysfunction. Suppressed glial activation and showed protective effect on motor neuron loss.
体外研究：
6-deoxyjacareubin 抑制密封室缺氧 (1 % O2) 和化学诱导的缺氧 (CoCl2) 在 HEK293T 细胞和其他类型的细胞系如 HT1080 (人肉瘤细胞系)、Neuro2a (小鼠神经母细胞瘤细胞系)和 MO3.13 (人少突胶质细胞系) 中诱导的细胞毒性。
6-Deoxyjacareubin is a natural xanthone, that can be isolated from the leaves of Vismia latifolia. 6-Deoxyjacareubin protects against non-apoptotic cell death by inhibiting ROS production. 6-Deoxyjacareubin ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis (ALS).
体内研究：
6-Deoxyjacareubin (5 mg/kg, Intraperitoneally (i.p.), every seven days for 1 month) attenuates motor neuron loss in familial ALS model mice.Animal Model:Male SOD1G93A mice (eight weeks)
Dosage:5 mg/kg
Administration:Intraperitoneally (i.p.), every seven days for 1 month
Result:Prolonged the survival time of SOD1G93A mice and improved their locomotor dysfunction. Suppressed glial activation and showed protective effect on motor neuron loss.
体外研究：
6-deoxyjacareubin 抑制密封室缺氧 (1 % O2) 和化学诱导的缺氧 (CoCl2) 在 HEK293T 细胞和其他类型的细胞系如 HT1080 (人肉瘤细胞系)、Neuro2a (小鼠神经母细胞瘤细胞系)和 MO3.13 (人少突胶质细胞系) 中诱导的细胞毒性。
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