产品
编 号：F194764
分子式：C14H21N5O2S
分子量：323.41
分子式：C14H21N5O2S
分子量：323.41
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
764
In-stock
5mg
1680
In-stock
10mg
2688
In-stock
25mg
4840
In-stock
结构图
CAS No: 1622902-68-4
产品详情
生物活性：
Abrocitinib (PF-04965842) is a potent, orally active and selective JAK1 inhibitor, with IC50s of 29 and 803 nM for JAK1 and JAK2, respectively. Abrocitinib (PF-04965842) exhibits less active effect on TYK2 (IC50, 1.253 μM), and inhibits phosphorylation of STAT1, STAT3 and STAT5 after stimulation. Effective in autoimmune disease.
体内研究：
Abrocitinib (Compound 25; 5, 15, 50 mg/kg, p.o., daily for 7 days) significantly reduces paw swelling in rat adjuvant-induced arthritis model.Animal Model:Female Lewis rats (8?10 weeks old)
Dosage:5, 15, 50 mg/kg
Administration:P.O. daily for 7 days
Result:Obviously reduced paw swelling at all doses.
体外研究：
Abrocitinib (Compound 25) inhibits IFNα-stimulated phosphorylation of STAT3, IFN-stimulated phosphorylation of STAT1 in human whole blood (HWB), as well as pSTAT5 in CD34+ spiked into HWB (JAK2), with IC50s of 189, 163 nM, 7.178 μM, respectively.
Abrocitinib (PF-04965842) is a potent, orally active and selective JAK1 inhibitor, with IC50s of 29 and 803 nM for JAK1 and JAK2, respectively. Abrocitinib (PF-04965842) exhibits less active effect on TYK2 (IC50, 1.253 μM), and inhibits phosphorylation of STAT1, STAT3 and STAT5 after stimulation. Effective in autoimmune disease.
体内研究：
Abrocitinib (Compound 25; 5, 15, 50 mg/kg, p.o., daily for 7 days) significantly reduces paw swelling in rat adjuvant-induced arthritis model.Animal Model:Female Lewis rats (8?10 weeks old)
Dosage:5, 15, 50 mg/kg
Administration:P.O. daily for 7 days
Result:Obviously reduced paw swelling at all doses.
体外研究：
Abrocitinib (Compound 25) inhibits IFNα-stimulated phosphorylation of STAT3, IFN-stimulated phosphorylation of STAT1 in human whole blood (HWB), as well as pSTAT5 in CD34+ spiked into HWB (JAK2), with IC50s of 189, 163 nM, 7.178 μM, respectively.
产品资料
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