产品
编 号：F194604
分子式：C23H19ClN2O6S
分子量：486.92
分子式：C23H19ClN2O6S
分子量：486.92
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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结构图
CAS No: 1622006-09-0
产品详情
生物活性：
Radioprotectin-1 is a potent and specific nonlipid agonist of lysophosphatidic acid receptor 2 (LPA2), with an EC50 value of 25 nM for murine LPA2 subtype.
体内研究：
Radioprotectin-1 is a high-potency specific agonist of the murine LPA2 GPCR .Radioprotectin-1 (0.1 mg/kg, 0.3 mg/kg; s.c.; every 12 hours; for 3 days) decreases the mortality of C57BL/6 mice in models of the hematopoietic acute radiation syndromes (HE-ARS) and gastrointestinal acute radiation syndromes (GI-ARS) .Radioprotectin-1 exerts its radioprotective and radiomitigative action through specific activation of the upregulated LPA2 GPCR in Lgr5+stem cells.Animal Model:8-10 weeks old C57BL/6 female mice bearing total body irradiation (TBI)
Dosage:0.1 mg/kg, 0.3 mg/kg
Administration:Subcutaneous injection; every 12 hours; for 3 days
Result:Decreased mortality of C57BL/6 mice in models of the HE-ARS and the GI-ARS.
体外研究：
Radioprotectin-1 is a potent agonist of LPA2 with an EC50 of 5 pM and functions as a full agonist at the human ortholog of LPA2.Radioprotectin-1 (0-3 μM; 15 minutes) effectively reduces apoptosis induced by γ-irradiation and the radiomimetic drug Adriamycin in cells that expressed LPA2 either endogenously or after transfection.
Radioprotectin-1 is a potent and specific nonlipid agonist of lysophosphatidic acid receptor 2 (LPA2), with an EC50 value of 25 nM for murine LPA2 subtype.
体内研究：
Radioprotectin-1 is a high-potency specific agonist of the murine LPA2 GPCR .Radioprotectin-1 (0.1 mg/kg, 0.3 mg/kg; s.c.; every 12 hours; for 3 days) decreases the mortality of C57BL/6 mice in models of the hematopoietic acute radiation syndromes (HE-ARS) and gastrointestinal acute radiation syndromes (GI-ARS) .Radioprotectin-1 exerts its radioprotective and radiomitigative action through specific activation of the upregulated LPA2 GPCR in Lgr5+stem cells.Animal Model:8-10 weeks old C57BL/6 female mice bearing total body irradiation (TBI)
Dosage:0.1 mg/kg, 0.3 mg/kg
Administration:Subcutaneous injection; every 12 hours; for 3 days
Result:Decreased mortality of C57BL/6 mice in models of the HE-ARS and the GI-ARS.
体外研究：
Radioprotectin-1 is a potent agonist of LPA2 with an EC50 of 5 pM and functions as a full agonist at the human ortholog of LPA2.Radioprotectin-1 (0-3 μM; 15 minutes) effectively reduces apoptosis induced by γ-irradiation and the radiomimetic drug Adriamycin in cells that expressed LPA2 either endogenously or after transfection.
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