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编 号：F194487
分子式：C23H27F2N5O4
分子量：475.49
分子式：C23H27F2N5O4
分子量：475.49
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CAS No: 1621332-91-9
产品详情
生物活性：
Nesvategrast (SF0166) is a potent and selective αvβ3 antagonist with IC50 values of 0.6 nM, 8 nM, and 13 nM for αvβ3, αvβ6, and αvβ8, respectively. Nesvategrast inhibits cellular adhesion to vitronectin across human, rat, rabbit, and dog cell lines with IC50 values of 7.6 pM to 76 nM. Nesvategrast decreases neovascularization in the oxygen-induced retinopathy mouse model.
体内研究：
Nesvategrast (双侧眼局部滴注 5% Nesvategrast) 抑制 129SVE 新生小鼠氧诱导视网膜病变 (OIR) 模型视网膜新生血管。Animal Model:Female 129SVE newborn mice with oxygen-induced retinopathy (OIR) models
Dosage:5% SF0166
Administration:Bilateral eye topical drip 5% SF0166
Result:Reduced new blood vessel formation.
体外研究：
Nesvategrast (0.5-4 μg; 12天; 鸡胚绒毛尿囊膜 (CAM) 模型) 以剂量依赖的方式抑制碱性成纤维细胞生长因子刺激的血管生成。
Nesvategrast (SF0166) is a potent and selective αvβ3 antagonist with IC50 values of 0.6 nM, 8 nM, and 13 nM for αvβ3, αvβ6, and αvβ8, respectively. Nesvategrast inhibits cellular adhesion to vitronectin across human, rat, rabbit, and dog cell lines with IC50 values of 7.6 pM to 76 nM. Nesvategrast decreases neovascularization in the oxygen-induced retinopathy mouse model.
体内研究：
Nesvategrast (双侧眼局部滴注 5% Nesvategrast) 抑制 129SVE 新生小鼠氧诱导视网膜病变 (OIR) 模型视网膜新生血管。Animal Model:Female 129SVE newborn mice with oxygen-induced retinopathy (OIR) models
Dosage:5% SF0166
Administration:Bilateral eye topical drip 5% SF0166
Result:Reduced new blood vessel formation.
体外研究：
Nesvategrast (0.5-4 μg; 12天; 鸡胚绒毛尿囊膜 (CAM) 模型) 以剂量依赖的方式抑制碱性成纤维细胞生长因子刺激的血管生成。
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