产品
编 号：F194459
分子式：C18H17F3N4O2S
分子量：410.41
分子式：C18H17F3N4O2S
分子量：410.41
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 162112-37-0
产品详情
生物活性：
RWJ 50271 is an selective and orally active inhibitor of lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction with an IC50 of 5.0 μM (HL60 cells). RWJ 50271 inhibits LFA-1/ICAM-1-mediated cell adhesion.
体内研究：
RWJ 50271 (50 mg/kg; p.o.) is effective in animal model of inflammation.Animal Model:Mice, the delayed-type hypersensitivity [DTH] reaction model
Dosage:50 mg/kg
Administration:Oral administration
Result:Significantly reduced foot pad swelling (>50%) 48 h after the challenge.
体外研究：
RWJ 50271 inhibits adhesion of peripheral blood lymphocytes to plastic immobilized SICAM-1.RWJ 50271 inhibits both human and murine NK activity (IC50=5.0 μM) in an LFA-1/ICAM-1-dependent natural killer [NK] cytotoxicity assay.RWJ 50271 does not inhibit Mac-1/ICAM-1, E-selectidsialyl Lewis X or VLA-4/VCAM-1-mediated cell adhesion up to 20 μM concentrations.RWJ 50271 does not alter the LFA-1 expression levels on HL60 cells.RWJ 50271 inhibits adhesion of peripheral blood lymphocytes to plastic immobilized SICAM-1.RWJ 50271 does not exhibit any toxic activity up to 100 μM concentrations.
RWJ 50271 is an selective and orally active inhibitor of lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction with an IC50 of 5.0 μM (HL60 cells). RWJ 50271 inhibits LFA-1/ICAM-1-mediated cell adhesion.
体内研究：
RWJ 50271 (50 mg/kg; p.o.) is effective in animal model of inflammation.Animal Model:Mice, the delayed-type hypersensitivity [DTH] reaction model
Dosage:50 mg/kg
Administration:Oral administration
Result:Significantly reduced foot pad swelling (>50%) 48 h after the challenge.
体外研究：
RWJ 50271 inhibits adhesion of peripheral blood lymphocytes to plastic immobilized SICAM-1.RWJ 50271 inhibits both human and murine NK activity (IC50=5.0 μM) in an LFA-1/ICAM-1-dependent natural killer [NK] cytotoxicity assay.RWJ 50271 does not inhibit Mac-1/ICAM-1, E-selectidsialyl Lewis X or VLA-4/VCAM-1-mediated cell adhesion up to 20 μM concentrations.RWJ 50271 does not alter the LFA-1 expression levels on HL60 cells.RWJ 50271 inhibits adhesion of peripheral blood lymphocytes to plastic immobilized SICAM-1.RWJ 50271 does not exhibit any toxic activity up to 100 μM concentrations.
产品资料
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