产品
编 号：F194418
分子式：C19H16ClN3O
分子量：337.8
分子式：C19H16ClN3O
分子量：337.8
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CAS No: 162100-15-4
产品详情
生物活性：
SB-215505 is a potent and subtype-selective 5-HT2B receptor antagonist with pKi values of 8.3, 6.77, 7.66 for 5-HT2B, 5-HT2A, 5-HT2C, respectively. SB-215505 increases wakefulness and motor activity in rats.
体内研究：
SB-215505 (0.1-1.0 mg/kg; i.p.; two doses) dose-dependently increases wakefulness (W) and decreases IS, PS, SWS-2.Animal Model:Male Sprague-Dawley rats weighing 230-260 g
Dosage:0.1, 0.3 and 1.0 mg/kg
Administration:IP; two doses (4 days between two doses)
Result:Dose-dependently increased wakefulness (W) and decreased intermediate stage of sleep (IS), paradoxical sleep (PS), SWS-2.
体外研究：
SB-215505 is 30 fold selective for the 5-HT2B over the 5-HT2A receptor, and only marginally selective over the 5-HT2C receptor.
SB-215505 is a potent and subtype-selective 5-HT2B receptor antagonist with pKi values of 8.3, 6.77, 7.66 for 5-HT2B, 5-HT2A, 5-HT2C, respectively. SB-215505 increases wakefulness and motor activity in rats.
体内研究：
SB-215505 (0.1-1.0 mg/kg; i.p.; two doses) dose-dependently increases wakefulness (W) and decreases IS, PS, SWS-2.Animal Model:Male Sprague-Dawley rats weighing 230-260 g
Dosage:0.1, 0.3 and 1.0 mg/kg
Administration:IP; two doses (4 days between two doses)
Result:Dose-dependently increased wakefulness (W) and decreased intermediate stage of sleep (IS), paradoxical sleep (PS), SWS-2.
体外研究：
SB-215505 is 30 fold selective for the 5-HT2B over the 5-HT2A receptor, and only marginally selective over the 5-HT2C receptor.
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