产品
编 号:F194328
分子式:C20H24F3N5O2
分子量:423.43
产品类型
结构图
CAS No: 1620574-24-4
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产品详情
生物活性:
DLK-IN-1 is a selective, orally active inhibitor of dual leucine zipper kinase (DLK, MAP3K12), with a Ki of 3 nM. DLK-IN-1 retains excellent CNS penetration and is well tolerated following multiple days of dosing at concentrations that exceed those required for DLK inhibition in the brain. DLK-IN-1 has activity in a model of Alzheimer’s Disease.