产品
编 号：F194266
分子式：C28H33N3O6
分子量：507.58
分子式：C28H33N3O6
分子量：507.58
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
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10mg
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25mg
询价
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50mg
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100mg
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结构图
CAS No: 162042-44-6
产品详情
生物活性：
L-371,257 is an orally bioavailable, non-blood-brain barrier penetrant, selective and competitive antagonist of oxytocin receptor (pA2=8.4) with high affinity at both the oxytocin receptor (Ki=19 nM) and vasopressin V1a receptor (Ki=3.7 nM).
体内研究：
全身给予非渗透性催产素受体拮抗剂 L-371,257 (0.5 和 1.0 mg/kg；腹腔注射) 刺激大鼠体重增加。Animal Model:Six-hour fasted rats
Dosage:0.5 and 1.0 mg/kg
Administration:Intraperitoneal injection (a single) 30-45 minutes prior to the start of the dark cycle and access to food; Intraperitoneal injection (given repeatedly) over 6 days.
Result:A single injection significantly stimulated weight gain at 0.5 and 1.0 mg/kg relative to vehicle treatment. When given repeatedly over 6 days, 0.5 mg/kg significantly stimulated body weight gain (10.5±2.2 g) relative to vehicle treatment (4.7±2.7 g).
L-371,257 is an orally bioavailable, non-blood-brain barrier penetrant, selective and competitive antagonist of oxytocin receptor (pA2=8.4) with high affinity at both the oxytocin receptor (Ki=19 nM) and vasopressin V1a receptor (Ki=3.7 nM).
体内研究：
全身给予非渗透性催产素受体拮抗剂 L-371,257 (0.5 和 1.0 mg/kg；腹腔注射) 刺激大鼠体重增加。Animal Model:Six-hour fasted rats
Dosage:0.5 and 1.0 mg/kg
Administration:Intraperitoneal injection (a single) 30-45 minutes prior to the start of the dark cycle and access to food; Intraperitoneal injection (given repeatedly) over 6 days.
Result:A single injection significantly stimulated weight gain at 0.5 and 1.0 mg/kg relative to vehicle treatment. When given repeatedly over 6 days, 0.5 mg/kg significantly stimulated body weight gain (10.5±2.2 g) relative to vehicle treatment (4.7±2.7 g).
产品资料
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