产品
编 号：F194256
分子式：C23H35N5O2
分子量：413.56
分子式：C23H35N5O2
分子量：413.56
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 1620401-82-2
产品详情
生物活性：
UNC0379 is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 (KMT5A) with an IC50 of 7.3 μM, KD value of 18.3 μM. UNC0379 can be used in the research of inflammation and cancers, such as pulmonary fibrosis, ovarian cancer, neuroblastoma.
体内研究：
UNC0379 (intratracheal administration, 1 mg/kg/day, on day7, 8, and 9) ameliorates the lung fibrosis in Bleomycin (BLM)-induced lung fibrosis mouse.Animal Model:Bleomycin (BLM)-induced lung fibrosis mouse model
Dosage:1 mg/kg/day
Administration:Intratracheal administration, on day7, 8, and 9.
Result:Ameliorated BLM-induced lung fibrosis (supported by the evaluation of the Ashcroft score and changes in the collagen content in the lung samples) without affecting pulmonary inflammation.
体外研究：
UNC0379 (1-10 μM, 9 days) inhibits HGSOC cells proliferation.?UNC0379 (10 μM, 96 h) increases in the proportion of sub-G1 phase cells in HGSOC cells.?UNC0379 (10 μM, 48 h) induces myofibroblast de-differentiation and inhibits additional fibroblast to myofibroblast differentiation.
UNC0379 is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 (KMT5A) with an IC50 of 7.3 μM, KD value of 18.3 μM. UNC0379 can be used in the research of inflammation and cancers, such as pulmonary fibrosis, ovarian cancer, neuroblastoma.
体内研究：
UNC0379 (intratracheal administration, 1 mg/kg/day, on day7, 8, and 9) ameliorates the lung fibrosis in Bleomycin (BLM)-induced lung fibrosis mouse.Animal Model:Bleomycin (BLM)-induced lung fibrosis mouse model
Dosage:1 mg/kg/day
Administration:Intratracheal administration, on day7, 8, and 9.
Result:Ameliorated BLM-induced lung fibrosis (supported by the evaluation of the Ashcroft score and changes in the collagen content in the lung samples) without affecting pulmonary inflammation.
体外研究：
UNC0379 (1-10 μM, 9 days) inhibits HGSOC cells proliferation.?UNC0379 (10 μM, 96 h) increases in the proportion of sub-G1 phase cells in HGSOC cells.?UNC0379 (10 μM, 48 h) induces myofibroblast de-differentiation and inhibits additional fibroblast to myofibroblast differentiation.
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