产品
编 号:F194229
分子式:C22H18Cl4O4
分子量:488.19
产品类型
结构图
CAS No: 1620160-42-0
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产品详情
生物活性:
Honokiol DCA (Honokiol dichloroacetate) is a dichloroacetate analog of Honokiol. Honokiol DCA can inhibit the growth of human prostate cancer cells in vitro and suppress the androgen receptor (AR) protein level.
体内研究:
Honokiol类似物
体外研究:
Honokiol DCA (20-40 μM; 24-48 h) inhibits the viability of LNCaP and C4-2 cells in a dose-and time-dependent manner.Honokiol DCA (5-20 μM; 10 days) inhibits clonogenicity of prostate cancer cells.Honokiol DCA (20-40 μM; 24-48 h) significantly decreases the level of androgen receptor (AR) and prostate specific antigen (PSA) protein in LNCaP cells.Honokiol DCA (40 μM; 24 h) significantly decreases AR promoter activity in LNCaP and C4-2 cells.