产品
编 号：F194171
分子式：C21H23N7O2
分子量：405.45
分子式：C21H23N7O2
分子量：405.45
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CAS No: 1619971-30-0
产品详情
生物活性：
Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship. Autotaxin-IN-1 is used in treatment of osteoarthritis pain.
体内研究：
Autotaxin-IN-1 (i.v.; 1.0mg/kg) has T1/2 of 1.14 hours.Autotaxin-IN-1 (p.o.; 10 mg/kg) has Cmax of 660 nM and AUC of 3440 nM?h.Animal Model:Normal rat
Dosage:1.0 mg/kg, 10 mg/kg (Pharmacokinetic Study)
Administration:I.v. (1.0 mg/kg); p.o. (10 mg/kg)
Result:Has T1/2 of 1.14 hours (i.v.; 1.0mg/kg).Has Cmax of 660 nM and AUC of 3440 nM?h (p.o.; 10 mg/kg).
Autotaxin-IN-1 is a potent autotaxin inhibitor, which has favorable potency (IC50=2.2 nM), PK properties, and a robust PK/PD relationship. Autotaxin-IN-1 is used in treatment of osteoarthritis pain.
体内研究：
Autotaxin-IN-1 (i.v.; 1.0mg/kg) has T1/2 of 1.14 hours.Autotaxin-IN-1 (p.o.; 10 mg/kg) has Cmax of 660 nM and AUC of 3440 nM?h.Animal Model:Normal rat
Dosage:1.0 mg/kg, 10 mg/kg (Pharmacokinetic Study)
Administration:I.v. (1.0 mg/kg); p.o. (10 mg/kg)
Result:Has T1/2 of 1.14 hours (i.v.; 1.0mg/kg).Has Cmax of 660 nM and AUC of 3440 nM?h (p.o.; 10 mg/kg).
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